Abstract：Objective: To analyze the correlation between the severity of heart failure and heart rate variability in patients with heart failure (hereinafter referred to as heart failure) with ventricular arrhythmia.Methods: 123 patients with heart failure and ventricular arrhythmia were selected prospectively as observation group, 30 patients without ventricular arrhythmia treated continuously in the same period were set as the control group. The basic diseases, NYHA cardiac function classification and left ventricular ejection fraction (LVEF) were compared between the two groups. The relationship between the severity of disease and heart rate variability (HRV) was analyzed based on the cardiac function classification. According to the follow-up results, the risk factors of cardiovascular composite endpoint events were analyzed. Results: In terms of HRV parameter time domain indexes (SDANN, SDNN Index, SDANN Index, RMSSD, PNN50) and frequency domain indexes (HF, LF, VLF), the indexes of the observation group were significantly lower than those of the control group (P<0.05). There were significant differences in the indicators of patients with different cardiac function classifications in the observation group (P<0.05). Among them, the HRV parameters of patients in grade Ⅳ were significantly lower than those in grades Ⅱ and Ⅲ (P<0.05). The classification showed a significant negative correlation (P<0.05). In terms of cardiovascular composite endpoint events, 68 cases (44.4%) occurred, combined ventricular arrhythmia occurred significantly more, and each HRV parameter index was significantly lower than the non-occurring group (P<0.05); COX analysis results showed that, SDANN Index, LF, and combined ventricular arrhythmia are risk factors (P<0.05). Conclusion: The severity of heart failure patients with ventricular arrhythmia is significantly negatively correlated with heart rate variability; SDANN index, LF, and ventricular arrhythmia are risk factors of cardiovascular composite endpoint events, HRV parameter detection could help to assess the condition and predict the prognosis, and the time period needed to be focused is 2-4 months after the first 12 lead Holter.
梁见弟, 叶继亮, 姚永钊, 刘巧茹, 陈丽玲. 合并室性心律失常的心衰患者病情严重程度与心率变异变化的相关性分析[J]. 河北医学, 2021, 27(4): 644-650.
LIANG Jiandi, YE Jiliang, YAO Yongzhao, et al. An of the correlation between severity of heart failure and heart rate variability in patients with ventricular arrhythmia. HeBei Med, 2021, 27(4): 644-650.
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2021, Vol. 27 
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