Abstract：Objective: To explore the related factors and the effect of small tidal volume ventilation in the treatment of children with acute hypoxic respiratory failure.Methods: 100 children with acute hypoxic respiratory failure from January 2018 to December 2019 were selected and randomly divided into observation group (treated with low tidal volume ventilation) and control group (treated with conventional ventilation) based on random number table, with 50 cases in each group. The changes of blood gas index, serum inflammatory factor index and cure effect were compared between the two groups before and after treatment; based on the observation of cure results, univariate and multivariate logistic regression analysis was used to explore the high-risk factors affecting the cure effect of neap tide ventilation. Results: There was no significant difference in PO2 / FiO2 and OI between the two groups (P>0.05) at the time of operation. At 24h, 48h and 72h after the operation, the observation group had significantly higher PO2 / FiO2 and OI was significantly lower than the control group. It has statistical significance (P<0.05). Before treatment, there was no significant difference in the levels of IL-6, IL-8 and TNF-α between the two groups (P>0.05). After treatment, the levels of IL-6, IL-8 and TNF-α in the observation group were significantly lower than those in the control group , The differences were statistically significant (P<0.05). The cure rate of the observation group (72.00%) was significantly higher than that of the control group (42.00%), the difference was statistically significant (P<0.05). The results of single factor analysis showed that there were significant differences in the age of cured and uncured children, the time from onset to presentation, ventilation time, acute lung injury, sepsis, and severe pneumonia in the observation group (P<0.05). Multivariate logistic regression analysis showed that age ≤20 months, time from onset to visit> 3d, ventilation time ≤48h, deformed lung injury, and sepsis were independent risk factors that affected the curative effect of the observation group (P<0.05). Conclusion: The small tidal volume ventilation program has a significant clinical effect on children with acute hypoxic respiratory failure, which can improve blood gas indexes, effectively reduce inflammatory reactions, and facilitate the recovery of children; age ≤20 months, time from onset to visit> 3d, ventilation time ≤48h, deformed lung injury, and sepsis are independent risk factors that affect the curative effect of the small tidal volume ventilation program. Therefore, targeted interventions can be taken to improve the prognosis of children.
王宝丹, 王超, 高于, 黄晓玲. 小潮气量通气治疗急性低氧性呼吸衰竭患儿的效果及其相关因素研究[J]. 河北医学, 2021, 27(4): 633-639.
WANG Baodan, et al. The Related Factors and the Effect of Low Tidal Volume Ventilation on Children with Acute Hypoxic Respiratory Failure. HeBei Med, 2021, 27(4): 633-639.
2021, Vol. 27 
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