盆腔超声在特发性中枢性性早熟女童诊断中的临床应用价值

doi:10.3969/j.issn.1006-6233.2021.04.019

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摘要 目的: 探讨盆腔超声在特发性中枢性性早熟(Idiopathic central precocious puberty,ICPP)女童诊断中的临床应用价值。方法: 回顾性分析我院及汕头潮南民生医院2019年1月至2020年1月20例采用盆腔超声诊断ICPP女童的临床资料,对临床及实验室确诊为真性性早熟的20例女童与27例正常女童进行盆腔超声检查,检查其子宫上下径、前后径、左右径、容积,左右卵巢大小、容积、超过4mm的最大卵泡直径,将盆腔超声的测量数据做相关性分析并采用ROC曲线诊断其工作效能,计算其曲线下面积。结果: 使用Mann-Whitney U法分析得出,真性性早熟组与正常组子宫、左右卵巢各项数值比较,均高于后者;相关性分析结果中得出,盆腔超声测量左右卵巢及子宫各数据结果呈现正相关,盆腔声检测子宫(上下径、前后径、左右径、容积)效能的AUC依次为0.985、0.822、0.967、0.831,敏感度依次为95%、80%、90%、85%,特异度依次为92.6%、77.8%、100%、70.4%;盆腔超声检测左卵巢(上下径、左右径、前后径、容积)效能AUC依次为0.976、0.805、0.946、0.784,敏感度依次为95%、75%、85%、50%,特异度依次为100%、74.1%、85.2%、100%;盆腔超声检测患者右卵巢(上下径、前后径、左右径、容积)AUC依次为0.991、0.839、0.983、0.828,敏感度依次为90%、75%、95%、60%,特异度依次为100%、77.8%、88.9%、96.3%,组间差异均具有统计学意义(P<0.05)。结论: 盆腔超声诊断ICPP女童效能较高,值得为临床提供借鉴参考。

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关键词 ：盆腔超声, 特发性中枢性性早熟, 子宫, 卵巢, 真性性早熟

Abstract：Objective: To explore the clinical value of pelvic ultrasound in the diagnosis of idiopathic central precocious puberty (ICPP) girls.Methods: A retrospective analysis was conducted with the clinical data of 20 cases of ICPP diagnosed by pelvic ultrasound in the First Affiliated Hospital and Shantou Chaonan Minsheng Hospital from January 2019 to January 2020 . 27 cases of normal precocious puberty diagnosed clinically and laboratorily were enrolled as controls. The girl underwent a pelvic ultrasound examination to check the upper and lower diameters, anteroposterior diameter, left and right diameters, volume of the uterus, left and right ovarian size, volume, and maximum follicle diameter exceeding 4mm. Correlation analysis of pelvic ultrasound measurement data and diagnosis of its work was carried out using ROC curve. For efficiency, the area under the curve was calculated. Result: Using the Mann-Whitney U method to analyze, the values of the uterus and left and right ovaries of the true precocious puberty group and the normal group are higher than the latter; the correlation analysis results show that the pelvic ultrasound measurement results of the left and right ovaries and uterus have positive correlation. The AUCs of the effectiveness of pelvic acoustic detection of the uterus (upper and lower diameter, anterior and posterior diameter, left and right diameter, volume) are 0.985, 0.822, 0.967, 0.831, and the sensitivity data are 95%, 80%, 90%, 85%, specificity data are 92.6%, 77.8%, 100%, 70.4%;The AUCs of the left ovary (upper and lower diameter, left and right diameter, anteroposterior diameter, volume) of patients detected by pelvic ultrasound are 0.976, 0.805, 0.946, 0.784, and the sensitivity data are 95%, 75%, 85%, 50%, the specificity data are 100%, 74.1%, 85.2%, 100%; the AUCs of the right ovary (upper and lower diameter, anteroposterior diameter, left and right diameter, volume) of patients detected by pelvic ultrasound are 0.991, 0.839 , 0.983, 0.828, the sensitivity data are 90%, 75%, 95%, 60%, and the specificity data are 100%, 77.8%, 88.9%, 96.3%, and the differences between groups are statistically significant (P<0.05) . Conclusion: The effectiveness of pelvic ultrasound in diagnosing ICPP girls is high, which is worthy of reference for clinical practice.

Key words： Pelvic ultrasound Idiopathic central precocious puberty Uterus Ovaries Precocious puberty

基金资助:广东省汕头市科技计划医疗卫生项目,(编号:181128194010168)

通讯作者: 栗丽

引用本文:

姚怀齐, 姚凡, 吴文慧, 栗丽. 盆腔超声在特发性中枢性性早熟女童诊断中的临床应用价值[J]. 河北医学, 2021, 27(4): 614-620.
YAO Huaiqi, et al. The Clinical Value of Pelvic Ultrasound in the Diagnosis of Idiopathic Central Precocious Puberty Girls. HeBei Med, 2021, 27(4): 614-620.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.04.019 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I4/614