Abstract：Objective: To investigate the analgesic effect, hemodynamics and serum inflammation of patient-controlled intravenous analgesia (PCIA) combined with thoracic paravertebral nerve block (TPVB) or erector spinal muscle plane block (ESPB) on lung cancer thoracotomy The influence of factors.Methods: 126 patients who underwent thoracotomy for lung cancer in Nanchong Central Hospital and Leshan People's Hospital from January 2017 to December 2019 were selected as the research objects, and were simply randomly divided into the PE group (PCIA combined with ESPB) and the PT group (PCIA combined with TPVB) based on the random number table method. 63 cases each group. To compare the analgesic effect, serum inflammatory factor levels, and blood flow force at the time of administration, induction, intubation, and extubation of the two groups immediately after surgery, 12h after surgery, 24h after surgery, and 48h after surgery Learning changes. Results: The visual analogue scale (VAS) scores of resting state and coughing state of the two groups increased with time and then decreased (P<0.05). The PT group was significantly lower than the PE group at 12h, 24h, and 48h after operation (P<0.05). There were no significant differences in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) in the PT group during induction, intubation, extubation, and block administration (P>0.05). In the PE group, HR, SBP and DBP tend to change with time (P<0.05). HR, SBP induction and intubation in the PT group were significantly lower than those in the PE group (P<0.05), and DBP induction was significantly lower than in the PE group (P<0.05) . The tumor necrosis cell α (TNF-α), interleukin-6 (IL-6), and interleukin-10 (IL-10) in the two groups at 12h, 24h, and 48h after surgery were significantly higher than those immediately after surgery (P<0.05), TNF-α and IL-6 in the PT group were significantly lower than those in the PE group (P<0.05), and IL-10 was significantly higher than the PE group (P<0.05). Conclusion: Compared with PCIA combined with TPVB, PCIA combined with ESPB has a better analgesic effect on lung cancer thoracotomy, and has more stable hemodynamics, which can effectively reduce inflammatory reactions.
范成龙, 吴勇, 周鑫, 王体芬. PCIA联合TPVB或ESPB对肺癌开胸手术镇痛效果血流动力学及血清炎性因子影响[J]. 河北医学, 2021, 27(4): 567-571.
FAN Chenglong, et al. The Analgesic Effect Hemodynamics and Serum Inflammatory Factors of PCIA Combined with TPVB or ESPB in Thoracotomy for Lung Cancer. HeBei Med, 2021, 27(4): 567-571.
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2021, Vol. 27 
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