Clinical Effect of Dachaihu Decoction on Acute Pelvic Inflammation and its Effect on Secretory Immunoglobulin A and Serum CRP
ZHANG Yamin, ZHANG Liran, et al
Heilongjiang Provincial Hospital of Traditional Chinese Medicine / Heilongjiang College of Traditional Chinese Medicine, Heilongjiang Harbin 150000, China
摘要目的: 探讨大柴胡汤治疗急性盆腔炎的临床疗效及对患者血清分泌型免疫球蛋白A(sIgA)、C反应蛋白(CRP)的影响。方法: 选择在2018年12月至2020年5月期间诊治的急性盆腔炎患者144例,随机数字表法分为观察组和对照组,各72例。对照组给予头孢西丁钠和盐酸多西环素治疗,观察组在对照组的基础上联合大柴胡汤治疗,对比两组治疗前后的盆腔积液、盆腔包块和血清炎性因子[CRP、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)]、sIgA水平变化,对比分析临床疗效与治疗期间的不良反应发生情况。结果: 观察组治疗总有效率高于对照组(97.22% vs 84.72%,P<0.05)。与治疗前比较,观察组与对照组治疗后盆腔积液和盆腔包块水平均下降(P<0.05),且观察组盆腔积液和盆腔包块水平低于对照组(P<0.05)。观察组治疗后血清CRP、TNF-α、IL-6水平均低于对照组,sIgA水平高于对照组(P<0.05)。观察组治疗期间不良反应发生率低于对照组(8.33% vs 20.83%,P<0.05)。结论: 大柴胡汤治疗急性盆腔炎有较好的临床疗效,可减少盆腔积液和盆腔包块大小,降低机体炎症因子并改善其免疫功能,降低不良反应发生率,值得推广。
Abstract：Objective: To investigate the clinical effect of Dachaihu Decoction on acute pelvic inflammation and its effect on serum secretory immunoglobulin A(sIgA) and C-reactive protein(CRP). Methods: 144 patients with acute pelvic inflammatory disease from December 2018 to May 2020 were randomly divided into two groups, 72 cases in each group. The control group was treated with cefoxitin sodium and doxycycline hydrochloride. The observation group was treated with Dachaihu Decoction on the basis of the control group. The pelvic effusion, pelvic mass, serum inflammatory factors [CRP, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6)] and sIgA before and after treatment were compared between the two groups. The clinical efficacy and the occurrence of adverse reactions during treatment were recorded and compared between two groups. Results: The effective rate of treatment in the observation group was higher than that in the control group (97.22% vs.84.72%) (P<0.05). Compared with before treatment, the level of pelvic effusion and pelvic mass in the observation group and the control group after treatment were decreased (P<0.05), and the level of pelvic effusion and pelvic mass in the observation group was lower than that in the control group (P<0.05). The levels of CRP, TNF-α and IL-6 in the observation group after treatment were lower than those in the control group, and the levels of sIgA were higher than that in the control group (P<0.05). The rate of adverse reactions in the observation group during treatment was lower than that in the control group (8.33% vs 20.83%)(P<0.05). Conclusion: Dachaihu decoction has better clinical efficacy in the treatment of acute pelvic inflammation, reducing pelvic effusion and pelvic mass size, reducing body inflammatory factors and improving immune function, and reducing the adverse reactions, which is worthy of promotion.
张亚敏, 张立然, 时思毛. 大柴胡汤治疗急性盆腔炎的临床疗效及对患者血清分泌型免疫球蛋白A CRP的影响[J]. 河北医学, 2021, 27(2): 326-330.
ZHANG Yamin, ZHANG Liran, et al. Clinical Effect of Dachaihu Decoction on Acute Pelvic Inflammation and its Effect on Secretory Immunoglobulin A and Serum CRP. HeBei Med, 2021, 27(2): 326-330.
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2021, Vol. 27 
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