Efficacy of Dipyridamole Combined with Gamma Globulin and Aspirin in the Treatment of Kawasaki Disease and its Effects on Immune Function and Coagulation Function of Children Patients
WANG Ru, et al
Qionghai People' s Hospital, Hainan Qionghai 571400, China
Abstract：Objective: To investigate the efficacy of dipyridamole combined with gamma globulin (intravenous immunoglobulin, IVIG) and aspirin in the treatment of Kawasaki disease (KD) and its effects on immune function and coagulation function of children patients. Methods: 150 children patients with KD were selected and divided into control group and observation group according to the random number table method, with 75 cases in each group. Control group was treated with aspirin tablets + IVIG, and observation group was treated with dipyridamole on the basis of the above medications, and they were treated for 6~8 weeks. The relief times of clinical symptoms, and peripheral blood T lymphocyte subsets and coagulation function indexes before and after treatment were observed in the two groups. The coronary artery injury after treatment was counted in the two groups. Results: The relief times of fever, diffuse mucosal hyperemia, trunk erythema, cervical lymph node swelling and conjunctival hyperemia in observation group were significantly shorter than those in control group (P<0.05). After treatment, the percentage of peripheral blood CD4+ T lymphocyte subsets and the ratio of CD4+/CD8+ T lymphocyte subsets in the two groups were significantly lower than those before treatment (P<0.05) while the percentage of CD8+ T lymphocyte subsets was significantly higher than that before treatment (P<0.05). The level of plasma fibrinogen (Fbg) in the two groups was significantly lower than that before treatment (P<0.05), and the changes in observation group were significantly greater than those in control group (P<0.05). After treatment, the degree of coronary artery injury in observation group was significantly less than that in control group (P<0.05), and the total incidence rate of coronary artery injury in observation group was significantly lower than that in control group (13.33% vs 40.00%) (P<0.05). Conclusion:Dipyridamole combined with IVIG and aspirin has exact efficacy in treating KD. It can significantly enhance the immune function, improve the coagulation dysfunction, and reduce the coronary artery injury.
王茹, 周莉蓉, 戚昌丽. 双嘧达莫联合丙种球蛋白及阿司匹林治疗川崎病疗效及对患儿免疫功能和凝血功能的影响[J]. 河北医学, 2021, 27(2): 317-321.
WANG Ru, et al. Efficacy of Dipyridamole Combined with Gamma Globulin and Aspirin in the Treatment of Kawasaki Disease and its Effects on Immune Function and Coagulation Function of Children Patients. HeBei Med, 2021, 27(2): 317-321.
2021, Vol. 27 
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