Abstract：Objective: To investigate the expression and clinical significance of serum vasohibin-1(VASH-1) in patients with type 2 diabetic nephropathy (DN). Methods: 252 patients with DN were selected as the research group for prospective study. According to the urinary albumin excretion rate (UAER), they were divided into normal albuminuria group (NA group, n=83), microalbuminuria group (MA group, n=85) and large albuminuria group (LA group, n=84). 85 healthy people in the same period were selected as the control group. 24 hours urine was collected for UAER detection, and venous blood was collected for VASH-1, transforming growth factor-β1(TGF-β1), C-reactive protein (CRP),glycosylated hemoglobin(HbA1c) and erythrocyte sedimentation rate(ESR) detection, which were compared among the groups, and the correlation between VASH-1 and other indexes was analyzed. Results: The levels of VASH-1,TGF-β1,UAER,CRP,HbA1c and ESR in the research group were significantly higher than those in the control group. The comparison between the two groups was statistically significant(P<0.05).The levels of research in NA group, MA group and LA group were as follows: LA group> MA group>NA group; the comparison among the three groups was statistically significant(P<0.05).Pearson correlation analysis showed that VASH-1 was positively correlated with TGF-β1, UAER, CRP, HbA1c and ESR (r=0.526, 0.646, 0.529, 0.273, 0.592, P<0.01). Multiple linear regression analysis showed that TGF-β1, UAER, CRP, HbA1c and ESR were independent risk factors for the change of serum VASH-1 level in DN patients. Conclusion: The increased expression of serum VASH-1 in DN patients is closely related to TGF-β1 and inflammatory markers, which provides a new way to study the mechanism of inflammation and fibrosis, to assist diagnosis, to explore therapeutic targets and to develop new drugs in diabetic renal injury.
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2021, Vol. 27 
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