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河北医学  2021, Vol. 27 Issue (12): 2010-2013    DOI: 10.3969/j.issn.1006-6233.2021.12.016
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HMGB1 NLR PCT与新生儿败血症危重程度的相关性研究
温艳, 刘军, 王凤东, 刘海红, 杨春光, 董志伟, 王晓静
河北省承德市妇幼保健院, 河北 承德 067000
The Correlation Between NLR PCT HMGB1 and Severity of Neonatal Septicemia
WEN Yan, LIU Jun, WANG Fengdong, et al
Maternity and Childcare Hospital, Hebei Chengde 067000, China
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摘要 目的: 探讨高迁移率族蛋白1(HMGB1)、降钙素原(PCT)、中性粒细胞/淋巴细胞比值(NLR)与新生儿败血症危重程度的相关性。方法: 收集2016年10月至2021年3月在我院治疗,最终确诊为新生儿败血症的患儿76例,根据新生儿危重病例评分法(NCIS),将患儿分为危重组38例,非危重组38例,比较两组一般资料及NLR、PCT及HMGB1水平,分析与新生儿败血症危重程度的相关性。结果: 败血症危重组的NLR、PCT及HMGB1水平均高于非危重组(t=15.424,6.206,9.994,P<0.001,0.001,0.001)。NLR、PCT、HMGB1水平与新生儿危重症评分呈负相关。对NLR、PCT、HMGB1进行串联、并联实验,结果显示三个指标的并联试验的灵敏度为78.9%,特异度为57.9%,三个方法的串联试验的灵敏度为71.1%,特异度为97.4%。结论: NLR、PCT、HMGB1串联应用对特异度有明显提升,临床上可考虑以上三个指标的串联应用,以减少对新生儿危重症的误诊误判的发生,对危重症的评估有一定的参考价值。
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关键词 高迁移率族蛋白1中性粒细胞/淋巴细胞比值降钙素原危重程度新生儿败血症    
AbstractObjective: To observe the value of NLR、PCT combined with HMGB1 in severity assessment of Neonatal septicemia. Methods:A total of 76 children with Neonatal septicemia were enrolled as examination group from October 2016 to March 2021. According to the Neonatal septicemia critical illness score, they were divided into critical group (n=38) and non-critical group (n=38). Blood was collected and tested for abnormal values, HMGB1 and PCT. Receiver operating characteristic (ROC) curve was employed to analyze the cut-off value of NLR、HMGB1 and PCT. Results: The level of NLR, PCT and HMGB1 in critical group were higher than the non-critical group(t=15.424,6.206,9.994,P<0.001,0.001,0.001). Serum PCT, HMGB1 and CRP levels are negatively correlated with NICS of Neonatal septicemia. The sensitivity and specificity of NLR, PCT, HMGB1 by parallel test are 78.9%, 57.9%. The sensitivity and specificity of NLR,PCT,HMGB1 by series test are 71.1%,97.4%. Conclusion: The sensitivity and specificity of NLR, PCT, HMGB1 by series rest are 71.1%, 97.4%, which shows that the series test can obviously improve the specificity. The series application of NLR、PCT、HMGB1 can be considered clinically to reduce the occurrence of misdiagnosis.
Key wordsHMGB1    NLR    PCT    Severity    Neonatal septicemia
    
基金资助:河北省承德市科技计划项目,(编号:202006A008)
通讯作者: 刘军   
引用本文:   
温艳, 刘军, 王凤东, 刘海红, 杨春光, 董志伟, 王晓静. HMGB1 NLR PCT与新生儿败血症危重程度的相关性研究[J]. 河北医学, 2021, 27(12): 2010-2013.
WEN Yan, LIU Jun, WANG Fengdong, et al. The Correlation Between NLR PCT HMGB1 and Severity of Neonatal Septicemia. HeBei Med, 2021, 27(12): 2010-2013.
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