Abstract：Objective: To observe the value of NLR、PCT combined with HMGB1 in severity assessment of Neonatal septicemia. Methods:A total of 76 children with Neonatal septicemia were enrolled as examination group from October 2016 to March 2021. According to the Neonatal septicemia critical illness score, they were divided into critical group (n=38) and non-critical group (n=38). Blood was collected and tested for abnormal values, HMGB1 and PCT. Receiver operating characteristic (ROC) curve was employed to analyze the cut-off value of NLR、HMGB1 and PCT. Results: The level of NLR, PCT and HMGB1 in critical group were higher than the non-critical group(t=15.424,6.206,9.994,P<0.001,0.001,0.001). Serum PCT, HMGB1 and CRP levels are negatively correlated with NICS of Neonatal septicemia. The sensitivity and specificity of NLR, PCT, HMGB1 by parallel test are 78.9%, 57.9%. The sensitivity and specificity of NLR,PCT,HMGB1 by series test are 71.1%,97.4%. Conclusion: The sensitivity and specificity of NLR, PCT, HMGB1 by series rest are 71.1%, 97.4%, which shows that the series test can obviously improve the specificity. The series application of NLR、PCT、HMGB1 can be considered clinically to reduce the occurrence of misdiagnosis.
[1] 王辉,任健康,王明贵.临床微生物学检验[M].第1版.北京:人民卫生出版社,2015.365~369. [2] 中华医学会急诊学分会儿科学组,中华医学会儿科学分会急诊学组,中华医学会儿科学分新生儿学组,新生儿危重病例评分法(草案)[J].中华儿科杂志,2001,39(1):42~43. [3] 段军,邓少华,邓涛,等.MLR、CEA和CA19-9联合检测的胃间质瘤的临床诊断价值[J].国际检验医学杂志,2020,41(8):927~930. [4] Omichi K,Cloyd JM,Yamashita S,et al.Neutrophil-to-lymphocyte ratio ptrdicts prognosis after neoadjuvant chemotherapy and resection of intrahepatic cholangiocarcinoma[J].Surgery,2017,164(4):752~765. [5] Che-Morales J L,Cortes-Telles A.Neutrophil-to-lymphocyte ratio as a serum biomarker associated with community acquired pneumonia [J].Rev Med Inst Mex Seguro SOC,2019,56(6):537~543. [6] 刘建军,刘光辉.中性粒细胞与淋巴细胞比值对脓毒血症患者预后评估的临床价值[J].新乡医学院学报,2016,33(5):425~428. [7] 陈素云,赵志新,颜海希,等.中性粒细胞/淋巴细胞比率和前蛋白对脓毒血症患者预后评价研究[J].中国卫生检验杂志,2019,29(20):2524~2527,2533. [8] 李园,齐荣,程雨嘉,等.降钙素原与新生儿败血症的相关性分析[J].中国妇幼健康研究,2019,30(10):1196~1200. [9] Deng M,Tang Y,Li W,et al.The endotoxin delivery protein HMGB1 mediates caspase-11-dependent lethality in sepsis[J].Immunity,2018,49(4):740~753. [10] Parker TM,Nguyen AH,Rabang JR,et al.The danger zone:systematic review of the role of HMGB1 danger signalling in traumatic brain injury[J].Brain Inj,2017,31(1):2~8. [11] 王思云,余加林.降钙素原在新生儿早发型败血症中的诊断价值[J].中国当代儿科杂志,2020,22(4):316~322.
2021, Vol. 27 
冀公网安备13080202000677号