Abstract：Objective: To observe the value of NLR、PCT combined with HMGB1 in severity assessment of Neonatal septicemia. Methods:A total of 76 children with Neonatal septicemia were enrolled as examination group from October 2016 to March 2021. According to the Neonatal septicemia critical illness score, they were divided into critical group (n=38) and non-critical group (n=38). Blood was collected and tested for abnormal values, HMGB1 and PCT. Receiver operating characteristic (ROC) curve was employed to analyze the cut-off value of NLR、HMGB1 and PCT. Results: The level of NLR, PCT and HMGB1 in critical group were higher than the non-critical group(t=15.424,6.206,9.994,P<0.001,0.001,0.001). Serum PCT, HMGB1 and CRP levels are negatively correlated with NICS of Neonatal septicemia. The sensitivity and specificity of NLR, PCT, HMGB1 by parallel test are 78.9%, 57.9%. The sensitivity and specificity of NLR,PCT,HMGB1 by series test are 71.1%,97.4%. Conclusion: The sensitivity and specificity of NLR, PCT, HMGB1 by series rest are 71.1%, 97.4%, which shows that the series test can obviously improve the specificity. The series application of NLR、PCT、HMGB1 can be considered clinically to reduce the occurrence of misdiagnosis.
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2021, Vol. 27 
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