Abstract：Objective: To explore the relationship between the distribution of plasma low-density lipoprotein (LDL) subtypes and the severity, prognosis of senile coronary heart disease (SCHD) patients. Methods: A total of 192 SCHD patients who were hospitalized in Cardiology Department of our hospital from December 2018 to October 2019 were selected as the research objects (observation group), and 189 cases with normal coronary artery examination were selected as the control group. The levels of blood lipid were measured by automatic biochemical analyzer; the LDL subtypes were electrophoretic separated by linear polyacrylamide gel. The quantitative analysis of LDL subtypes was completed by high-precision scanning; the correlation between plasma LDL3, small and dense LDL (sdLDL) and Gensini score was analyzed by Pearson method. Results: The levels of plasma triglyceride (TG), total cholesterol (TC) and LDL cholesterol (LDL-C), LDL3, ldl4, ldl5, ldl6, ldl7 and sdLDL in the observation group were significantly higher than those in the control group, and the level of plasma high density lipoprotein cholesterol (HDL-C) was significantly lower than that in the control group (P<0.05). The levels of plasma LDL3 and sdLDL in single vessel group, double vessel group and three vessel group were significantly increased in turn (P<0.05). The levels of plasma LDL3 and sdLDL in the high Gensini score group were significantly higher than those in the low and middle score groups, the levels of plasma LDL3 and sdLDL in middle Gensini score group were significantly higher than those in low score group (P<0.05). The levels of plasma LDL3 and sdLDL in SCHD patients were positively correlated with Gensini score (r / P = 0.536/0.000, 0.521/0.000). The levels of plasma LDL3 and sdLDL in poor prognosis group were significantly higher than those in good prognosis group (P<0.05). Logistic regression analysis showed that LDL3, sdLDL and Cr were independent risk factors for the severity of SCHD patients. while age, sdLDL and Gensini score were independent risk factors for the prognosis of SCHD patients (P<0.05). Conclusion: The levels of LDL3 and sdLDL in different subtypes of plasma LDL in SCHD patients are significantly increased, which are related to the increase of the number of diseased branches, the increase of Gensini score and the occurrence of MACE.
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2021, Vol. 27 
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