Abstract：Objective: To explore the short-term effect and safety of uniportal video-assisted thoracoscopic surgery (VATS) lobectomy for patients with early-stage lung cancer. Methods: The clinical data of 107 patients with early-stage lung cancer in our hospital undergoing VATS lobectomy during January 2017 and January 2020 were retrospectively reviewed. They were divided into uniportal group (n=55) and multi-port group (n=52) according to the surgical procedure. The patients underwent VATS lobectomy, and mediastinal lymph node dissection. The operation time, intraoperative blood loss, number of the harvested lymph node, the visual analogue scale (VAS), numerical rating scale (NRS), serum interleukin-6 (IL-6) and IL-8 after surgery of the patients in the two groups were recorded and compared. The complications within 6 months after surgery in both groups were also recorded. Results: The operation time in uniportal group was longer than the multi-port group; whereas the intraoperative blood loss was more than the multi-port group, without significant difference between the two groups (P>0.05). Furthermore, there was no significant difference in the number of lymph node dissection between the two groups (P>0.05, respectively). Moreover, the VAS, NRS, serum IL-6 and IL-8 of the paitents in uniportal group were significantly lower than those in the multi-port group (P<0.05, respectively). Additionally, the overall incidence of complications within 6 months after surgery in the uniportal group was similar to the multi-port group (P>0.05). Conclusion: Uniportal VATS lobectomy was feasible and safe in patients with early-stage lung cancer, and it can alleviate postoperative pain and inflammation stress.
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2021, Vol. 27 
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