Abstract：Objective: To analyze the correlation between peripheral blood microrna-208 (mir-208), soluble growth stimulating gene 2 protein (sST2), clusterin (CLU) and left ventricular remodeling (LVR) in patients with acute myocardial infarction (AMI). Methods: 62 patients with AMI diagnosed in our hospital from January 2019 to February 2020 were selected as AMI group. According to the LVR standard, AMI group was divided into left ventricular remodeling group (LVR group) and left ventricular non remodeling group (non-LVR group). At the same time, 35 outpatients who were tested negative by coronary angiography (stenosis < 50%) without any basic heart disease were selected as control group. The levels of high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), total cholesterol (TC), sST2, CLU , mir-208, fasting blood glucose (FPG), white blood cell (WBC) and platelet (PLT) were measured, and echocardiography was performed. The correlation between the levels of mir-208, sST2 and CLU in peripheral blood of IMA patients and echocardiographic indexes was analyzed. Results: Compared with the control group, the levels of LDL-C, mir-208, sST2, CLU, LVESD and LVEF in non-LVR group and LVR group were significantly higher than those in non-LVR group (P<0.05); the levels of LVEDd, LVESV, LVEDV and LVMI in no LVR group and LVR group were significantly lower than those in non-LVR group (P<0.05). Pearson correlation analysis showed that LVESD and LVEF were positively correlated with mir-208, sST2 and CLU (P<0.05), while LVESV, LVEDd, LVEDV and LVMI were negatively correlated with mir-208, sST2 and CLU (P<0.05). Conclusion: The levels of sST2 and CLU in peripheral blood of IMA patients are closely related to LVR. Timely detection of these two factors is helpful to inhibit the occurrence and development of LVR after AMI.
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2021, Vol. 27 
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