Abstract：Objective: To analyze the correlation between levels of serum hemoglobin A (HbA), hemoglobin F (HbF) and glucose-6-phosphate dehydrogenase (G-6-PD) and neonatal hyperbilirubinemia. Methods: A total of 106 neonates with neonatal hyperbilirubinemia admitted to the pediatric department of the hospital from February 2017 to February 2020 were selected as study group, and 106 normal neonates in the hospital at the same period were selected as control group. The neonates in study group were divided into mild group (n=55), moderate group (n=31) and severe group (n=20) according to the disease conditions of children patients with hyperbilirubinemia. The levels of serum HbA, HbF and G-6-PD were compared between study group and control group, and the correlation between levels of serum HbA, HbF and G-6-PD and neonatal hyperbilirubinemia was analyzed. Results: The levels of serum HbA and TBil of hyperbilirubinemia children patients in study group were significantly higher than those in control group (P<0.05), and the levels of serum HbF and G-6-PD were significantly lower than those in control group (P<0.05). The level of serum HbA of severe group was higher than that of mild group and moderate group (P<0.05), and the level of moderate group was higher than that of mild group (P<0.05), and the HbF level of severe group was lower than that of mild group and moderate group (P<0.05), and there was no significant difference in the G-6-PD level in each group (P>0.05). Serum HbA level of children patients with hyperbilirubinemia was positively correlated with TBil level (P<0.05), and HbF level was negatively correlated with TBil level (P<0.05), and the G-6-PD level was not obviously correlated with TBil level (P>0.05). Conclusion: The level of serum HbA is higher and the levels of HbF and G-6-PD are lower among neonates with hyperbilirubinemia, and the disease severity of children patients is related to the levels of HbA and HbF. Detection of serum HbA and HbF levels is helpful to evaluate the disease severity of neonates with hyperbilirubinemia.
2021, Vol. 27 
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