摘要目的:探究喷昔洛韦联合阿昔洛韦软膏治疗带状疱疹的疗效及患者疼痛、血清IL-2、IL-6水平变化情况。方法:选取2016年9月至2020年10月间本院收治的142例带状疱疹患者为研究对象,采用简单随机分组法分为观察组和对照组,71例/组。对照组采用常规软膏涂抹治疗,观察组在此基础上给予喷昔洛韦治疗。比较两组疗效、临床症状改善时间(带状疱疹结痂、水疱停止发展、疼痛消失时间);比较治疗前后两组患者神经痛评分(VAS);比较治疗前后两组血清炎症因子[白细胞介素-2(IL-2)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)]变化;比较治疗前后T细胞亚群[T淋巴细胞(T lymphocyte,CD3+)、辅助性T细胞(Helper T cells,CD4+)、细胞毒性T细胞(Cytotoxic T cells,CD8+)、CD4+/CD8+]变化;记录治疗期间不良反应发生率。结果:治疗7d后,观察组治疗有效率高于对照组(P<0.05);观察组临床症状改善时间均短于对照组(P<0.05);治疗后两组VAS评分均降低且观察组低于对照组(P<0.05);治疗后,两组IL-2、IL-10水平和CD3+、CD4+及CD4+/CD8+均升高,且观察组高于对照组(P<0.05);两组IL-6水平均下降,且观察组低于对照组(P<0.05)。治疗期间两组不良反应发生率无明显差异(P>0.05)。结论:喷昔洛韦联合阿昔洛韦软膏治疗带状疱疹的疗效显著,能缓解神经疼痛,缩短症状消退时间,调节炎症因子,提高免疫功能,且安全性高。
Abstract：Objective: To explore the curative effect of penciclovir combined with aciclovir ointment on herpes zoster and the changes of pain, serum interleukin-2 (IL-2) and interleukin-6 (IL-6) levels. Methods: A total of 142 patients with herpes zoster admitted to the hospital between September 2016 and October 2020 were enrolled as the research objects. They were divided into observation group and control group by simple random grouping method, 71 cases in each group. The control group was treated with routine ointment, while observation group was additionally treated with penciclovir. The curative effect and improvement time of clinical symptoms [scabbing time of herpes zoster, stopping development time of blisters, disappearance time of pain], scores of Visual Analogue Scale (VAS) before and after treatment, changes in levels of serum inflammatory factors [IL-2, IL-6, interleukin-10 (IL-10)] and T cell subsets [T lymphocyte (CD3+), Helper T cells (CD4+), Cytotoxic T cells (CD8+), CD4+/CD8+] before and after treatment were compared between the two groups. The incidence of adverse reactions during treatment was recorded. Results: At 7d after treatment, the response rate of treatment in observation group was higher than that in control group (P<0.05). The improvement time of clinical symptoms in observation group was shorter than that in control group (P<0.05). After treatment, VAS scores in both groups were decreased, which were lower in observation group than control group (P<0.05). After treatment, levels of IL-2 and IL-10, CD3+, CD4+ and CD4+/CD8+ in both groups were increased, which were higher in observation group than control group (P<0.05), while IL-6 level was decreased, which was lower in observation group than control group (P<0.05). There was no significant difference in the incidence of adverse reactions during treatment between the two groups (P>0.05). Conclusion: Curative effect of penciclovir combined with aciclovir ointment is significant on herpes zoster, it can relieve neuropathic pain, shorten disappearance time of symptoms, regulate inflammatory factors, and improve immune function, with high safety.
杨源锋, 苏圣贤, 解小丽. 喷昔洛韦联合阿昔洛韦软膏治疗带状疱疹的疗效及患者疼痛 血清IL-2 IL-6水平变化研究[J]. 河北医学, 2021, 27(10): 1719-1723.
YANG Yuanfeng, SU Shengxian, XIE Xiaoli. Curative Effect of Penciclovir Combined with Aciclovir Ointment on Herpes Zoster and the Changes of Pain Serum IL-2 and IL-6 Levels. HeBei Med, 2021, 27(10): 1719-1723.
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2021, Vol. 27 
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