Abstract：Objective: To observe the clinical effect of local injection of triamcinolone acetonide combined with semiconductor laser in the treatment of erosive oral lichen planus (EOLP). Methods: In this clinical trial, 62 patients selected according to the inclusion and exclusion criteria were randomly divided into two groups. One group received semiconductor laser therapy (300 MW, 2 times/day, 5 minutes/time) combined with local injection of triamcinolone acetonide (5mL∶ 50mg, once a week), while the control group was treated with triamcinolone acetonide alone, with the same dose and method as the experimental group. Before treatment and 2 weeks and 4 weeks after treatment, the clinical effects of patients with lesion size and pain were measured, recorded and statistically analyzed. Results: 2 weeks and 4 weeks after treatment, the lesion area and pain degree of the treatment group and the control group were significantly reduced. At 2 weeks, the average lesion and pain degree of the treatment group was less than that of the control group, but the difference was not statistically significant. At 4 weeks after treatment, the average lesion and pain degree of the treatment group were further less, and significantly less than that of the control group (P<0.05).Conclusion: The effect of triamcinolone acetonide combined with semiconductor laser in the treatment of erosive oral lichen planus is significant, which is better than that of triamcinolone acetonide alone.
张永军, 刘向伟, 刘锐. 曲安奈德局部注射联合半导体激光对糜烂型口腔扁平苔藓的治疗效果[J]. 河北医学, 2021, 27(10): 1710-1712.
ZHANG Yongjun, LIU Xiangwei. The Effect of Local Injection of Triamcinolone Acetonide Combined with Semiconductor Laser in the Treatment of Erosive Oral Lichen Planus. HeBei Med, 2021, 27(10): 1710-1712.
[1] 陈强,闫元元,卢恕来.激光在口腔黏膜病治疗中的研究进展[J].中华老年口腔医学杂志,2017,15(3):185~188,192. [2] Derikvand Nahid,Ghasemi Seyedeh Sara,Moharami Mohammad,et al.Management of oral lichen planus by 980 nm diode laser[J].Lasers Med Sci,2017,8(3):150~154. [3] 陈丽莉,何磊,齐海花,等.神经妥乐平联合脾氨肽治疗带状疱疹疗效观察[J].河北医学,2017,23(3):500~502. [4] 朱丹丹.CCL20/CCR6轴在口腔扁平苔藓病损组织的表达及意义[D].南京医科大学,2017. [5] 李姗,朱丹丹,范媛.CCR6-CCL20轴在口腔扁平苔藓黏膜组织中的表达及意义[J].口腔医学,2018,38(5):406~409. [6] Aastha Gupta,Kabir Sardana,Ram Kishan Gautam.Looking beyond the cyclosporine “swish and spit” technique in a recalcitrant case of erosive lichen planus involving the tongue[J].Case Rep Dermatol,2017,9(3):177~183. [7] 郑宇杰.康复新液联合曲安奈德局部注射治疗糜烂型口腔扁平苔藓的疗效分析[J].全科口腔医学电子杂志,2019,6(35):176~177. [8] Imran Majid.Fractional carbon dioxide laser in combination with topical corticosteroid:An innovative treatment for hypertrophic lichen planus[J].Journal of the American Academy of Dermatology,2017,77(3):67~68.
2021, Vol. 27 
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