Comparison of Effects of High-Flow Nasal Cannula and Non-Invasive Positive Pressure Ventilation on Oxygenation Index and Respiratory Function in Patients with Acute Attack of Bronchial Asthma Complicated with Type 1 Respiratory Failure
BAO Jie, QIAO Qingzhe, LU Pei, et al
Hebei Chest Hospital, Hebei Shijiazhuang 050000, China
Abstract：Objective: To investigate the effects of high-flow nasal cannula (HFNC) and non-invasive positive pressure ventilation (NIPPV) on oxygenation index and respiratory function in patients with acute attack of bronchial asthma complicated with type 1 respiratory failure. Methods: A total of 160 patients with acute attack of bronchial asthma complicated with type 1 respiratory failure who were admitted between December 2017 and December 2019 were enrolled as the research subjects. The patients were divided into observation group and control group according to the simple random sampling of random number table method, with 80 cases in each group. Observation group was treated with HFNC oxygen therapy, and control group was treated with NIPPV oxygen therapy. Before treatment and after 24h of treatment, the oxygenation index (OI) and respiratory function [arterialpartial pressure of oxygen (PaO2), partial pressure of carbon dioxide (PaCO2)]and hemodynamics [heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP)] and comfort [Visual Numerical Score (VNS)] were evaluated in the two groups. The treatment conditions (oxygen therapy time, hospital stay length, invasive ventilation intubation rate) were compared between the two groups. Results: After 24h of treatment, the OI and PaO2 of the two groups were higher than those before treatment (P<0.05), and the increases in observation group were greater than those in control group (P<0.05), and there was no statistically significant difference in PaCO2 between the two groups before and after treatment (P>0.05). After 24h of treatment, the RR, HR, and MAP of the two groups were lower than those before treatment (P<0.05), and the decreases in observation group were greater than those in control group (P<0.05). After 24h of treatment, the comfort VNS scores of both groups were lower than those before treatment (P<0.05), and the decrease in observation group was greater than that in control group (P<0.05). The invasive ventilation intubation rate, oxygen therapy time and hospital stay in observation group were lower than those in control group (P<0.05). Conclusion: HFNC can provide better and more comfortable respiratory support for patients with asthma and type 1 respiratory failure, and has good application value.
鲍洁, 乔庆哲, 吕培, 贺向红. 经鼻高流量氧疗和无创正压通气对支气管哮喘急性发作伴1型呼吸衰竭患者氧合指数及呼吸功能的影响比较[J]. 河北医学, 2021, 27(10): 1705-1709.
BAO Jie, QIAO Qingzhe, LU Pei, et al. Comparison of Effects of High-Flow Nasal Cannula and Non-Invasive Positive Pressure Ventilation on Oxygenation Index and Respiratory Function in Patients with Acute Attack of Bronchial Asthma Complicated with Type 1 Respiratory Failure. HeBei Med, 2021, 27(10): 1705-1709.
2021, Vol. 27 
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