血尿酸水平 IL-2 IL-6和TNF-α水平与抑郁症患者抑郁症状及躯体化症状评分的相关性分析

doi:10.3969/j.issn.1006-6233.2021.10.013

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摘要 目的:研究血尿酸水平、白细胞介素-2(interleukin-2,IL-2)、白细胞介素-6(IL-6)和肿瘤坏死因子-α(tumour necrosis factor-α,TNF-α)水平与抑郁症患者抑郁症状及躯体化症状评分的相关性。方法:选择本院2018年2月至2020年10月诊治的177例抑郁症患者(研究组),另选择同期来本院体检的健康志愿者153例作为对照组,进行回顾性研究。均检测血尿酸水平、IL-2、IL-6和TNF-α水平,并采用汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)评估两组研究对象心理情况,分析血尿酸水平、炎症因子水平与抑郁症患者抑郁症状以及躯体化症状评分的相关性。结果:研究组患者血清IL-2、IL-6以及TNF-α水平显著高于对照组,血尿酸水平显著低于对照组(P<0.05);研究组研究对象HAMD量表各个项目评分均显著高于对照组(P<0.05);重度症状患者血清尿酸水平显著高于轻度、中度症状患者,血清IL-2、IL-6以及TNF-α水平显著高于轻度、中度症状患者(P<0.05);血清尿酸水平与抑郁症状严重程度呈负相关,血清IL-2、IL-6以及TNF-α水平与抑郁症状严重程度呈正相关(P<0.05);血清尿酸水平与焦虑/躯体化、日夜变化评分评分呈负相关(P<0.05),与其他因子无显著相关性(P>0.05),血清IL-2、IL-6以及TNF-α水平与焦虑/躯体化、日夜变化评分呈正相关(P<0.05),与其他因子无显著相关性(P>0.05)。结论:抑郁症患者存在血尿酸水平降低,IL-2、IL-6以及TNF-α水平升高的现象,且抑郁症症状严重程度、躯体化症状评分分别与血尿酸水平呈负相关,与IL-2、IL-6和TNF-α水平呈正相关。

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	孟云
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关键词 ：血尿酸, 白细胞介素-2, 抑郁症, 汉密尔顿抑郁评分, 肿瘤坏死因子-α

Abstract：Objective: To study the correlation of the levels of blood uric acid, interleukin-2(IL -2), IL-6, tumour necrosis factor-α(TNF-α) and inflammatory factors with scores of depressive symptoms and somatization symptom in patients with depression. Methods: This retrospective study included 177 patients with depression (study group) diagnosed and treated in the hospital between February 2018 and October 2020. Meanwhile, 153 healthy volunteers were selected as the control group. The levels of blood uric acid, interleukin-2 (IL-2), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were detected. The Hamilton Depression Scale (HAMD) was used to assess psychological states of the two groups. The correlation between the levels of blood uric acid and inflammatory factors and the scores of depressive symptoms and somatization symptom in patients with depression was analyzed. Results: The levels of serum IL-2, IL-6 and TNF-α in the study group were significantly higher than those in the control group, and the blood uric acid levels were significantly lower than those in the control group (P<0.05). The HAMD scores of the study group were significantly higher than those of the control group (P<0.05). The serum uric acid levels of patients with severe symptoms were significantly higher than those of patients with mild and moderate symptoms, while the levels of serum IL-2, IL-6 and TNF-α were significantly higher than those of patients with mild and moderate symptoms (P<0.05). Serum uric acid level was negatively correlated with the severity of depressive symptoms, while the levels of serum IL-2, IL-6 and TNF-α were positively correlated with the severity of depressive symptoms (P<0.05). Serum uric acid level was negatively correlated with the scores of anxiety/somatization and circadian changes (P<0.05), and there was no significant correlation with other factors (P>0.05). Serum IL-2, IL-6 and TNF-α levels were positively correlated with the scores of anxiety/somatization and circadian changes (P<0.05), but there was no significant correlation with other factors (P>0.05). Conclusion: The blood uric acid level is decreased, and inflammatory factor levels are elevated in patients with depression. The severity of depressive symptoms and somatization symptom scores are negatively correlated with blood uric acid level, and positively correlated with IL-2, IL6 and TNF-α levels.

Key words： Blood uric acid Interleukin-2 Depression Hamilton depression scale Tumour necrosis factor-α

基金资助:湖北省卫生健康委员会科研立项项目,(编号:WJ2019F095)

通讯作者: 李博

引用本文:

孟云, 李博. 血尿酸水平 IL-2 IL-6和TNF-α水平与抑郁症患者抑郁症状及躯体化症状评分的相关性分析[J]. 河北医学, 2021, 27(10): 1647-1651.
MENG Yun, LI Bo. The Correlation Between the Levels of Blood Uric Acid IL-2 IL-6 and TNF-α and Scores of Depressive Symptoms and Somatization Symptom in Patients with Depression. HeBei Med, 2021, 27(10): 1647-1651.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.10.013 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I10/1647

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