Abstract：Objective: To investigate the epidemiological characteristics, clinical characteristics and climatic factors of different subtypes of respiratory syncytial virus (RSV) in children. Methods: A total of 309 children with acute lower respiratory tract infection infected by RSV were collected from our hospital from January 2018 to December 2020. The epidemiological characteristics, clinical characteristics and climatic characteristics of different subtypes of RSV infection were analyzed; Spearman correlation was used to analyze the correlation between different RSV subtypes and climate characteristics. Results: Among the 309 cases of RSV, 186 cases (60.19%) of RSV-A and 123 cases (39.81%) of RSV-B were found, with RSV-A type as the dominant type; RSV-A and RSV-B groups showed statistically significant differences in different years and seasons (all P<0.05). In 2018 and 2019, RSV-B was the dominant infection group, and in 2020, RSV-A was the dominant infection group. Children infected with RSV-A and RSV-B were mainly infected under 3 years old, in winter and spring and had mild symptoms, there was no significant difference between RSV-A group and RSV-B group in terms of age and severity of disease (all P>0.05). There was no significant difference between RSV-A and RSV-B in fever, cough, wheezing, mixed infection and other clinical symptoms, course of disease and length of hospital stay (all P>0.05); Spearman correlation analysis showed that RSV-A infection was positively correlated with PM2.5, PM10, SO2, NO2 and CO (r=0.658, P<0.001; r = 0.612, P = 0.002; r = 0.501, P = 0.008; r = 0.728, P = 0.001; r =0.642, P<0.001), was negatively correlated with mean temperature, monthly total rainfall, monthly mean wind speed and O3 (r=-0.592, P=0.001; r = 0.502, P = 0.005; r = 0.618, P = 0.002; r =-0.654, P<0.001); RSV-B infection was positively correlated with CO (r=0.559, P<0.001), and negatively correlated with monthly mean temperature, monthly total rainfall and O3 (r=-0.581, P=0.001; r = 0.368, P = 0.025; r =-0.598, P<0.001). Conclusion: RSV-A type is the dominant type of RSV infection in children, and RSV-A type is the dominant type of RSV infection in children under 3 years old, winter and spring, and mild symptoms. Different subtypes of RSV infection are related to climate and environmental factors.
吴守业, 林道炯, 王亚洲. 儿童不同亚型呼吸道合胞病毒感染的临床流行特征及气候因素分析[J]. 河北医学, 2021, 27(10): 1632-1636.
WU Shouye, LIN Daojiong, WANG Yazhou. Clinical Epidemiological Characteristics and Climatic Factors of Different Subtypes of Respiratory Syncytial Virus Infection in Children. HeBei Med, 2021, 27(10): 1632-1636.
[1] Li Y,Johnson EK,Shi T,et al.National burden estimates of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in young children in 2019 among 58 countries:a modelling study[J].Lancet Respir Med,2021,9(2):175~185. [2] Bianchini S,Silvestri E,Argentiero A,et al.Role of respiratory syncytial virus in pediatric pneumonia[J].Microorganisms,2020,8(12):2048. [3] 任康轶,任洛,邓昱,等.2013年至2018年重庆地区2066例急性下呼吸道感染住院患儿呼吸道合胞病毒流行特征分析[J].中国当代儿科杂志,2021,23(1):67~73. [4] 中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童社区获得性肺炎管理指南(2013修订)(上)[J].中华儿科杂志,2013,51(10):745~752. [5] Shi T,McAllister DA,O'Brien KL,et al.RSV global epidemiology network.Global,regional,and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015:a systematic review and modelling study[J].Lancet,2017,390(10098):946~958., [6] Huang Y,Hua J,Wang D,et al.Risk factors of respiratory syncytial virus infection among pediatric influenza-like illness and severe acute respiratory infections in Suzhou,China[J].Med Virol,2018,90(3):397~404. [7] Griffiths C,Drews SJ,Marchant DJ.Respiratory syncytial virus:infection,detection and new options for prevention and treatment[J].Clin Microbiol Rev,2017,30(1):277~319. [8] Robledo-Aceves M,Moreno-Peregrina MJ,Velarde-Rivera F,et al.Risk factors for severe bronchiolitis caused by respiratory virus infections among Mexican children in an emergency department[J].Medicine (Baltimore),2018,97(9):e0057. [9] 周平,秦弦,谭忠友,等.小儿呼吸道合胞病毒A、B亚型的流行病学特征及临床表现[J].中国医药导报,2016,13(14):115~118. [10] Hibino A,Saito R,Taniguchi K,et al.Molecular epidemiology of human respiratory syncytial virus among children in Japan during three seasons and hospitalization risk of genotype ON1[J].PLoS One,2018,13(1):e0192085. [11] Vandini S,Biagi C,Lanari M.Respiratory syncytial virus:the influence of serotype and genotype variability on clinical course of infection[J].Int Mol Sci,2017,18(8):1717. [12] 周丹,王宇清.2013年至2015年苏州地区儿童呼吸道鼻病毒感染的流行病学特点与气候因素的相关性研究[J].儿科药学杂志,2018,24(8):8~11.
2021, Vol. 27 
冀公网安备13080202000786号