Abstract：Objective: To investigate the effect of dexmedetomidine on recovery quality and serum IL-1β and TNF-α levels in resuscitation stage of sevoflurane inhalation anesthesia . Methods: A total of 108 patients underwent laparoscopic cholecystectomy in our hospital from March 2016 to March 2020 were selected and randomly divided into two groups based on the random number table method, with 54 patients in each group. In the study group, dexmedetomidine was continuously pumped after sevoflurane inhalation, while in the control group, constant dose of normal saline was continuously pumped. Perioperative indicators, incidence of agitation and serum inflammatory factors (IL-1β, TNF-α) were compared. Results: There were no statistically significant differences in intraoperative infusion volume, recovery time of spontaneous breathing, tracheal extubation time or awakening time between the two groups (P>0.05).The generalized equation analysis showed that the incidence of agitation in waking period in the study group was lower than that in the control group at different time points (Waldχ2group=4.097, Waldχ2time point=30.388, Pgroup=0.043, Ptime point<0.001). Results of repeated measurement variance showed that VAS score, serum TNF- and IL-1 levels were significantly different between the two groups at different time points (P<0.05); The VAS score, serum TNF-α and IL-1β of the study group were significantly lower than those of the control group (P<0.05). Conclusion: Dexmedetomidine in sevoflurane inhalation anesthesia can effectively improve the postoperative recovery quality of patients, reduce restlessness of patients during convalescence, and has an important role in the reduction of inflammatory response in patients.
2021, Vol. 27 
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