痛风性关节炎患者苯溴马隆联合糖皮质激素治疗对患者临床效果与AST ALT UA水平的影响

doi:10.3969/j.issn.1006-6233.2021.01.029

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摘要 目的: 探讨痛风性关节炎患者苯溴马隆联合糖皮质激素治疗对患者临床效果与AST、ALT、UA水平的影响。方法: 选取本院2019年2月至2020年2月就诊的300例痛风性关节炎患者作为研究对象,将其根据数字随机法分为A组和B组各150例,A组采用秋水仙碱+糖皮质激素治疗,B组采用苯溴马隆联合糖皮质激素,比较两组患者的临床疗效以及AST、ALT、UA水平的变化。结果: A组患者显效78例,有效50例,无效22例,总有效率为85.33%;B组患者显效80例,有效60例,无效10例,总有效率为93.33%;两组患者总有效率经临床统计学分析,有差异性(P<0.05);两组患者的年龄、性别、BMI指标比较无统计学差异(P>0.05);而ALT、AST、UA各项指标中,B组指标明显优于A组,有显著统计学差异(P<0.05)。结论: 痛风性关节炎患者苯溴马隆联合糖皮质激素治疗对患者临床疗效显著,同时也应注意监测肝功能的变化。

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关键词 ：痛风性关节炎, 苯溴马隆, 糖皮质激素, 临床效果, 影响

Abstract：Objective: To investigate the effect of benzbromarone combined with glucocorticoid therapy on patients with gouty arthritis and its influence on the level of AST, ALT and UA. Methods: 300 patients with gouty arthritis who were treated in our hospital from February 2019 to February 2020 were selected as the research objects, and they were randomly divided into group A and group B with 150 cases each. Group A was treated with colchicine + Glucocorticoid therapy, group B was treated with benzbromarone combined with glucocorticoid, and the clinical efficacy and the changes of AST, ALT and UA levels were compared between the two groups. Results: In group A, 78 cases were markedly effective, 50 cases effective, 22 cases ineffective, and the total effective rate was 85.33%; Group B patients had 80 markedly effective cases, 60 cases effective , and 10 cases ineffective, with a total effective rate of 93.33%; The effective rate was analyzed by clinical statistics, and there was a difference (P<0.05); The two groups of patients had no statistical difference in age, gender, and BMI indicators (P>0.05); And among the ALT, AST, UA indicators, group B indicators were significantly better than group A, with significant statistical difference (P<0.05). Conclusion: Benzbromarone combined with glucocorticoid therapy in patients with gouty arthritis has a significant clinical effect on patients. At the same time, attention should be paid to monitoring changes in liver function.

Key words： Gouty arthritis Benzbromarone Glucocorticoid Clinical effect Influence

基金资助:河北省医学重点课题计划,(编号:20160303)

通讯作者: 郭海梅

引用本文:

卢晓静, 周志安, 苏彬, 郝凤杰, 王立东, 周桂荣, 邢晓芳, 郭海梅. 痛风性关节炎患者苯溴马隆联合糖皮质激素治疗对患者临床效果与AST ALT UA水平的影响[J]. 河北医学, 2021, 27(1): 125-127.
LU Xiaojing, ZHOU Zhi'an, SU Bin. The Clinical Effect of Benzbromarone Combined with Glucocorticoid Therapy on Patients with Gouty Arthritis and It's Influence on AST ALT UA Level. HeBei Med, 2021, 27(1): 125-127.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.01.029 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I1/125