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河北医学  2021, Vol. 27 Issue (1): 11-14    DOI: 10.3969/j.issn.1006-6233.2021.01.003
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他汀类对AMI患者急诊经皮冠状动脉介入治疗术后血脂IL-6 TNF-α和血液粘度的影响
韩雪, 陈丽杰
辽宁省丹东市中心医院循环内科, 辽宁 丹东 118000
Effects of Statins on Blood Lipid IL-6 TNF- α and Blood Viscosity After Emergency Percutaneous Coronary Intervention in Patients with AMI
HAN Xue, CHEN Lijie
Dandong Central Hospital, Liaoning Dandong 118000, China
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摘要 目的: 探讨他汀类对急性心肌梗死(AMI)患者急诊经皮冠状动脉介入术(PCI)后白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)和血液粘度的影响。方法: 选取我院于2017年12月至2018年8月期间收治的100例AMI患者,采用简单随机分组方法,分为对照组和试验组各50例。两组患者在住院治疗中均行PCI及相应药物治疗,而试验组加上口服瑞舒伐他汀,检测治疗前后血脂、IL-6、TNF-α和血液粘度。结果: 两组治疗后IL-6、TNF-α水平比起治疗前均有所降低,试验组比对照组降低更为明显(P<0.05)。血脂水平(HDL-C、LDL-C、TC、TG)较治疗前均明显改善,试验组比对照组改善更明显(P<0.05)。两组治疗后全血高切黏度(NBH)和全血低切黏度(NBL)比治疗前均有所降低,试验组降低得更为明显(P<0.05);实验组的血清IL-6、TNF-α、NBH与NBL水平增长明显大于对照组,差异有统计学意义(P<0.05)。结论: AMI患者急诊经皮冠状动脉介入治疗术后加用瑞舒伐他汀可明显抑制IL-6、TNF-α水平和血液粘度,同时可有效改善血脂水平。
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韩雪
陈丽杰
关键词 急性心肌梗死瑞舒伐他汀血 脂血液粘度经皮冠状动脉介入术    
AbstractObjective: To investigate the effects of statins on blood lipid, IL-6,TNF- α and blood viscosity after emergency percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods: A total of 100 patients with AMI treated in our hospital from December 2017 to August 2018 were randomly divided into two groups: control group (n = 50) and trial group (n = 50).The patients in both groups were treated with PCI and corresponding drug therapy. The blood lipid, IL-6,TNF- α and blood viscosity were measured and compared before and after treatment with rishovastatin in the groups. Results: After treatment, the level of IL-6,TNF- α in the two groups was lower than that before treatment, and that in the trial group was more obvious than that in the control group(P<0.05).The levels of blood lipid (HDL-C,LDL-C,TC,TG) were significantly improved in the treatment group than in the control group (P<0.05).After treatment, NBH and NBL in the two groups were lower than those before treatment, especially in the test group(P<0.05). Conclusion: After emergency PCI in patients with AMI, risuvastatin could significantly inhibit the level of IL-6,TNF- α and blood viscosity, and effectively improve the level of blood lipid.
Key wordsAcute myocardial infarction    Risuvastatin    Blood lipid    Blood viscosity    Percutaneous coronary intervention
    
基金资助:辽宁省自然科学基金项目,(编号:201702023)
引用本文:   
韩雪, 陈丽杰. 他汀类对AMI患者急诊经皮冠状动脉介入治疗术后血脂IL-6 TNF-α和血液粘度的影响[J]. 河北医学, 2021, 27(1): 11-14.
HAN Xue, CHEN Lijie. Effects of Statins on Blood Lipid IL-6 TNF- α and Blood Viscosity After Emergency Percutaneous Coronary Intervention in Patients with AMI. HeBei Med, 2021, 27(1): 11-14.
链接本文:  
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.01.003     或     http://www.hbyxzzs.cn/CN/Y2021/V27/I1/11
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