Abstract：Objective: To investigate the clinical characteristics of Corona Virus Disease 2019 (COVID-19) efficacy of convalescent plasma therapy. Methods: A total of 6 cases COVID-19 patients admitted to Wuhan Jinyintan Hospital and received convalescent plasma therapy from January 23, 2020 to April 26, 2020 were reviewed retrospectively, and the clinical characteristics as well as efficacy of convalescent plasma therapy were summarized and analyzed respectively. Results: According to the guideline for Diagnosis and Treatment of Novel Coronavirus Infected Pneumonia, 6 cases were divided into severe group (n=4) and critical group (n=2). The clinical symptoms of 6 cases included fever (6 cases), cough (6 cases), fatigue (3 cases), diarrhea (1 case). Ratio of lymphocyte decreased in 3 patients. High sensitivity troponin and glutamic-pyruvic transaminase raised in one patient, respectively. The manifestations of early lung CT images in severe group were ground-glass-like high density shadows scattered outside the lungs. CT images in critical group showed that diffuse ground-glass-like high density shadows, or cotton ball-like and reticular nodules consolidation change were formed in both lungs. On the basis of antiviral therapy, 6 patients were administrated with convalescent plasma. All patients were successful in plasma transfusion except one, who had a skin allergy, and was relieved after symptomatic treatment. After active treatment, symptoms and various indicators of these patients were improved, and finally, all patients were cured and discharged. Conclusion: Fever and cough are the first symptoms of COVID-19, accompanied by different degrees of systemic symptoms, Plasma therapy in convalescent period has certain application value in treating COVID-19, but the potential side effects of blood transfusion should be paid attention to.
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2021, Vol. 27 
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