Coagulation Function and Thromboelastography Detection in Patients with Acute Ischemic Stroke Treated with Blood Transfusion and Its Clinical Significance
QI Feng, HUANG Wei
The Affiliated Hospital of Yan'an University, Shaanxi Yan'an 716000, China
Abstract：Objective: To study the coagulation function and thromboelastography (TEG) detection in patients with acute ischemic stroke treated with blood transfusion and its clinical significance.Methods: 120 patients with acute ischemic stroke who were treated with endovascular therapy in our hospital from January 2017 to June 2019 were selected as the research object, and 34 health controls were selected as the control group.The indexes of TEG and conventional coagulation test, and TEG parameters including R time, K time, α angle, and maximum amplitude (MA) between the two groups were compared.Correlation between TEG and parameters of onventional coagulation test in patients with ischemic stroke was analyzed.The sensitivity, specificity, and accuracy of different methods in the diagnosis of complications such as cerebral hemorrhage and early neurological deterioration were calculated.Results: Compared with those in the control group, the T and R times of the TEG test indicators in the ischemic stroke group were significantly shorter, while the α angle and the MA value were significantly larger(P<0.05).The conventional coagulation test index APTT was significantly shorter than that of the control group, and the FIB concentration increased (P<0.05), indicating the hypercoagulable state.The T time and K time of the TEG test indexes in the complication group were significantly shorter than those in the non-complication group, while the α angle and MA value were significantly increased compared with those in the non-complication group (P<0.05).The index of routine coagulation test APTT was significantly shorter than that of the non-complication group, and the FIB concentration increased (P<0.05).R time was significantly positively correlated with PI and ATPP (P<0.05), but there was no significant correlation between R time and FBI (P>0.05).K time was negatively correlated with FBI, and α angle and MA were positively correlated with FIB (P<0.05).The above parameters of TEG test had no significant correlation with PI and ATPP (P>0.05).The sensitivity, specificity, and accuracy of TEG in the diagnosis of symptomatic cerebral hemorrhage were 77.78%, 89.19%, and 88.33%, respectively, and in the diagnosis of early neurological deterioration, 16.67%, 92.59% and 85.00%, respectively.The sensitivity, specificity, and accuracy of conventional coagulation tests in the diagnosis of symptomatic cerebral hemorrhage were 46.15%, 72.90%, and 70.00%, respectively, and in the diagnosis of early neurological deterioration, 58.33%、66.67%、65.83%, respectively.Conclusion: The parameters of TEG detection can effectively reflect the process of coagulation changes in patients with acute ischemic stroke, and have some correlation with the indicator levels of conventional coagulation test.In clinical practice, the appropriate detection method can be selected according to the actual situation of the patient.
齐峰, 黄伟. 急性缺血性脑卒中输血治疗患者凝血功能血栓弹力图检测及其临床意义[J]. 河北医学, 2020, 26(9): 1565-1570.
QI Feng, HUANG Wei. Coagulation Function and Thromboelastography Detection in Patients with Acute Ischemic Stroke Treated with Blood Transfusion and Its Clinical Significance. HeBei Med, 2020, 26(9): 1565-1570.
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2020, Vol. 26 
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