Abstract：Objective: To analyze the effects and safety of lanthanum carbonate in improving calcium and phosphorus levels in patients undergoing maintenance hemodialysis.Methods: A total of 92 patients who were expecting maintenance hemodialysis were divided into control group (n=46) and treatment group (n=46) with the simple random grouping method.Control group was treated with calcium carbonate, and treatment group was treated with lanthanum carbonate.After 2 months of treatment, levels of blood calcium, blood phosphorus, intact parathyroid hormone (iPTH) and serum 25-hydroxyvitamin D (25OHD) and changes of vascular endothelial function were compared between the two groups.Safety was evaluated.Results: There were no obvious changes in levels of blood calcium or iPTH before and after treatment (P>0.05), but blood phosphorus level was significantly decreased after treatment (P<0.05).The pre- and post-operative differences of blood calcium level and blood phosphorus level in treatment group were obviously greater than those in control group (P<0.05), but the pre- and post-operative difference of iPTH of the two groups was not statistically significant (P>0.05).The serum 25OHD level in treatment group was significantly increased after treatment (P<0.05), but there was no significant change in control group (P>0.05).The pre- and post-operative difference of serum 25OHD level in treatment group was greater than that in control group (P<0.05).The flow-mediated dilation (FMD) in treatment group was significantly increased after treatment (P<0.05) while the fibroblast growth factor-23 (FGF23) was significantly decreased after treatment (P<0.05).There were no obvious changes in FMD or FGF23 in control group before and after treatment (P>0.05).The pre- and post-operative differences of FMD and FGF23 in treatment group were greater than those in control group (P<0.05).At 1 week after the end of treatment, the review results of blood, liver and kidney function and electrocardiogram in the two groups were in normal range.There was no significant difference in the incidence rate of adverse reactions between the two groups (P>0.05).Conclusion: Effects of lanthanum carbonate are more obvious than calcium carbonate in the treatment of patients undergoing maintenance hemodialysis.The former can significantly reduce the blood phosphorus level, increase the serum 25OHD level and improve the vascular endothelial function, without causing changes in blood calcium level and with high safety.
吴丹, 刘胜阳, 任丽丽. 碳酸镧对维持性血液透析患者钙磷水平的影响及安全性分析[J]. 河北医学, 2020, 26(9): 1532-1536.
WU Dan, LIU Shengyang, REN Lili. The Analysis of the Effects of Lanthanum Carbonate on Calcium and Phosphorus Levels and Its Safety in Patients Undergoing Maintenance Hemodialysis. HeBei Med, 2020, 26(9): 1532-1536.
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2020, Vol. 26 
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