Abstract：Objective: To investigate the peripheral blood neuropeptide Y (NPY),cholecystokinin (CCK),and leptin (LEP) levels and their clinical significance in children with anorexia.Methods: A total of 105 children with anorexia pediatric patients treated in our hospital from January 2017 to August 2019 were prospectively selected as the observation group,and 102 children with healthy physical examinations in the same period were selected as the control group.Compared serum NPY,CCK,LEP levels and clinical symptom scores between two groups and children with different levels of illness,and analyzed the correlation between serum NPY,CCK,LEP and clinical symptoms,according to the average expression of serum NPY,CCK,and LEP,the patients were divided into high-expressed and low-expressed patients,the efficacy of children with different levels of serum NPY,CCK,and LEP was compared,and the relationship between the three was analyzed.Results: The serum NPY in the observation group was lower than that in the control group,and CCK and LEP were higher than those in the control group (P<0.05); serum NPY was lower in severe children than in moderate and mild children,and CCK and LEP were higher than in moderate and mild children (P<0.05); severe children with reduced food intake,fatigue,and fatigue scores were higher than those with moderate and mild children (P<0.05); serum NPY was negatively correlated with reduced appetite,fatigue,and fatigue scores,and CCK was positively correlated with reduced appetite,fatigue,and fatigue scores (P<0.05); the total effective rate of those with high expression of NPY in serum was higher than those with low expression,and the total effective rate of those with high expression of CCK and LEP was lower than those with low expression (P<0.05); serum NPY was positively correlated with curative effect,while CCK and LEP were negatively correlated with curative effect (P<0.05).Conclusion: The expressions of serum NPY,CCK and LEP are closely related to the severity of anorexia and treatment effect in children,clinical treatment can be formulated according to the expression of the above serum indicators to improve the treatment effect.
符日明, 陈运旺, 雷智贤, 梁振明. 小儿厌食症患儿外周血神经肽Y胆囊收缩素 LEP水平测定及临床意义[J]. 河北医学, 2020, 26(9): 1499-1504.
FU Riming, CHEN Yunwang, et al. Detection of Peripheral Blood Neuropeptide Y Cholecystokinin and LEP in Children with Anorexia and its Clinical Significance. HeBei Med, 2020, 26(9): 1499-1504.
[1] Emel Atas Berksoy,Goncaozyurt,Murat Anil,et al.Can pediatricians recognizeeating disorders:a case study of early-onset anorexia nervosa in a male child[J].Nutr Hosp,2018,35(1):499. [2] 刘汉玉,何红霞.参苓白术散联合布拉氏酵母菌治疗小儿厌食症的疗效及对食欲调节因子的影响[J].现代中西医结合杂志,2017,26(14):1549~1552. [3] Shi Z,Madden CJ,Brooks VL.Arcuate neuropeptide Y inhibits sympathetic nerve activity via multiple neuropathways.[J].Clin Invest,2017,127(7):2868~2880. [4] Chen VC,Chen CH,Chiu YH,et al.Leptin/Adiponectin ratio as a potential biomarker for metabolic syndrome in patients with schizophrenia[J].Psychone Uroendocrino,2018,92(1):34~40. [5] Maria Gutierrez-Mecinas,Andrew M Bell,Fraser Shepherd,等.Expression of cholecystokinin by neurons in mouse spinal dorsal horn[J].Comp Neurol,2019,527(11):24657. [6] 王超,康翠翠,冯江银,等.L-精氨酸对大鼠胃肠激素分泌及食欲的影响[J].草业学报,2019,28(6):167~174. [7] Karakuta-Juchnowicz H,Pankowicz H,Juchnowicz D,et al.Intestinal microbiota - A key to understanding the pathophysiology of anorexia nervosa[J].Psychiatr Pol,2017,51(5):859~870. [8] Foradori CD,Whitlock BK,Daniel JA,et al.Kisspeptin stimulates growth hormone release by utilizing neuropeptide Y pathways and is dependent on the presence of ghrelin in the ewe[J].Endocrinology,2017,158(10):3526~3539. [9] 卜秀梅,王文刚.六磨汤加味对便秘型肠易激综合征患者血清神经肽Y、P物质和5-羟色胺水平的影响[J].中国药业,2017,26(23):37~39. [10] 杨丽萍.功能性消化不良病儿应用双歧杆菌三联活菌胶囊联合多潘立酮的胃动力学指标分析[J].安徽医药,2019,23(5):1016~1020. [11] Kim DY,Yu J,Mui RK,et al.The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia ( anx ) mutation[J].Dis Model Mech,2017,10(5):581~595. [12] Holsen LM,Jackson B.Reward capacity predicts leptin dynamics during laboratory-controlled eating in women as a function of body mass index: reward capacity and leptin[J].Obesity (Silver Spring),2017,25(9):1564~1568. [13] 莫湘,黄大荣,刘松华,等.疏肝利胆清热中药治疗慢性胆囊炎疗效及对血清肿瘤坏死因子-α、瘦素水平的影响[J].现代中西医结合杂志,2017,26(10):1077~1079. [14] 徐鹏飞,荣阳,荣根满.功能性消化不良患者胃排空时间和血浆胃动素的相关性与临床研究[J].中国医药指南,2019,17(15):136~137. [15] 孙永峰.开胃消食合剂联合针刺四缝穴治疗小儿厌食症疗效观察[J].四川中医,2017,35(12):145~147.
2020, Vol. 26 
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