Abstract：Objective: To explore the connection between serum adiponectin (APN), leptin, 8-hydroxy-deoxyguanosine (8-OHdG) levels and pediatric epilepsy seizures, cognitive impairment.Methods: A total of 122 children with pediatric epilepsy who were admitted to the hospital from January 2017 to December 2019 were enrolled as study objects.According to children's cognitive function, they were divided into cognitive normal epilepsy group (82 cases) and cognitive impairment epilepsy group (40 cases).Sixty normal children who underwent physical examination in the same period were included in healthy control group.Cognitive function was evaluated by Wechsler Intelligence Scale for Children-IV(WISC-IV).The levels of serum APN, leptin and 8-OHdG were detected.The connection of serum APN, leptin and 8-OHdG levels with cognitive function in epilepsy children was analyzed.Logistic regression analysis was performed on cognitive impairment in epilepsy children.Results: In cognitive impairment epilepsy group, the level of serum APN was lower than that in cognitive normal epilepsy group and healthy control group (P<0.05), while level of leptin and 8-OHdG were higher (P<0.05).In cognitive normal epilepsy group, the level of serum APN was lower than that in healthy control group (P<0.05), while levels of leptin and 8-OHdG were higher (P<0.05).The level of serum APN was positively connected with the score of WISC-Ⅳ (r=0.385, P<0.05),while levels of leptin and 8-OHdG were negatively connected with the score of WISC-Ⅳ (r=-0.533, r=-0.428, P<0.05).The increase of APN (OR=0.583) is negatively connected with cognitive impairment.The increase of leptin (OR=1.826) and 8-OHdG (OR=2.849) is positively connected with cognitive impairment.Conclusion: The levels of serum APN, leptin and 8-OHdG are closely connected to seizures of pediatric epilepsy, which are also important factors that cause cognitive impairment.
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2020, Vol. 26 
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