Abstract：Objective: To analyze the distribution of pathogenic bacteria in diabetic foot patients and the correlation between serum inflammatory factors and disease condition and prognosis.Methods: The clinical data of 86 diabetic foot patients admitted to Jinan Central Hospital from January 2018 to May 2019 were selected and divided into mild infection group (30 cases), moderate infection group (33 cases) and severe infection group (23 cases) according to the infection degree of diabetic foot.As to the outcome of treatment, 28 cases were cured, 44 cases were improved and 14 cases were ineffective.At the same time, 78 health controls were made the control group.The distribution of pathogenic bacteria in diabetic foot patients was analyzed.The levels of serum procalcitonin (PCT), high sensitivity C-reactive protein (hs-CRP) and interleukin -6(IL-6) in each group were compared.Results: A total of 102 strains of pathogenic bacteria were isolated from 86 patients with diabetic foot.Gram-negative bacteria were dominant, mainly Pseudomonas aeruginosa and Acinetobacter baumannii, followed by Gram-positive bacteria, mainly Staphylococcus aureus and Staphylococcus epidermidis.The levels of serum inflammatory factors in diabetic foot infection groups with different degrees were higher than those in the control group, and the difference was statistically significant (P<0.05).The level of serum inflammatory factors in diabetic foot severe infection group was significantly higher than that in moderate infection group and mild infection group (P<0.05).The levels of serum inflammatory factors in patients with diabetic foot failure were significantly higher than those in the cured and improved groups, and the difference was statistically significant (P<0.05).Conclusion: The distribution of pathogenic bacteria in diabetic foot patients is dominated by gram-negative bacteria, and the level of serum inflammatory factors increases significantly with the aggravation of infection degree.In addition, the level of serum inflammatory factors can reflect the clinical effectiveness of diabetic foot patients.
王焱, 初晶学, 孙涛. 糖尿病足患者病原菌分布及血清炎性因子与病情及预后的相关性分析[J]. 河北医学, 2020, 26(9): 1413-1416.
WANG Yan, CHU Jingxue, et al. Analysis of Pathogen Distribution and the Correlation Between Serum Inflammatory Factors and Disease Condition and Prognosis in Diabetic Foot Patients. HeBei Med, 2020, 26(9): 1413-1416.
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2020, Vol. 26 
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