Abstract：Objective: To study clinical evaluation of magnesium valproate sustained release tablets combined with ziprasidone in treatment of bipolar disorder and effect on serum total bilirubin, albumin and inflammatory factors. Methods: 90 cases with bipolar disorder from October 2014 to October 2016 in our hospital were researched, and according to the random number table they were divided into treatment group and control group, 45 cases in each. Magnesium valproate sustained release tablet was administered to the control group, while the observation group was treated with magnesium valproate sustained release tablets combined with ziprasidone. They were compared on clinical treatment effect, serum albumin, total bilirubin and inflammatory factor levels, score of BRMS, Quality of Life and HAMD and safety. Results: After treatment, the difference between the total effective rate in treatment group (93.33%) and the total effective rate in the control group (77.78%) was statistically significant (P<0.05). The levels of serum albumin and total bilirubin in the treatment group were significantly higher than those in the control group (P<0.05), while the levels of inflammatory factors were significantly lower in the treatment group than in the control group (P<0.05). Scores of BRMS and HAMD in both groups were significantly decreased, while the life quality score was significantly increased, and the improvement of mania scale, Hamilton depression scale and life quality score in the treatment group was significantly better than that in the control group(P<0.05). Conclusion: The efficacy of magnesium valproate sustained release tablets combined with ziprasidone in the treatment of bipolar disorder was significant in reducing the score of BRMS and HAMD and improving serum total bilirubin, albumin, inflammatory factor levels, and it has less adverse reactions, being safe and reliable.
李艳, 何献策. 丙戊酸镁联合齐拉西酮治疗双相情感障碍的效果及对血清总胆红素白蛋白炎症因子水平的影响[J]. 河北医学, 2020, 26(8): 1307-1311.
LI Yan, HE Xiance. Efficacy of Valproic Acid Combined with Ziprasidone on Bipolar Disorder and Its Effect on Serum Total Bilirubin Albumin and Inflammatory Factors. HeBei Med, 2020, 26(8): 1307-1311.
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2020, Vol. 26 
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