Abstract：Objective: To study the regulatory effect of blue light irradiation combined with comprehensive treatment on serum indexes of hyperbilirubinemia caused by hemolytic disease of the newborn. Methods: 90 children with hyperbilirubinemia caused by hemolytic disease of the newborn were randomly divided into two groups: the intervention group was treated with blue light irradiation combined with comprehensive drug treatment; the control group was treated with comprehensive drug treatment. The levels of TBIL, MDA, neurofunctional molecules, liver and kidney functional molecules were detected before and after treatment. Results: With one case in the intervention group being ineffective, the total effective rate was 97.78% (44/45), significantly higher than that in the control group (χ2=10.88, P=0.001). There was no difference in serum TBIL content between the two groups before treatment; After treatment, the serum TBIL content of the intervention group was significantly lower than that of the contro group (P<0.05). Before the treatment, there was no significant difference in the content of α - glutathione-s transferase and serum glutamate dehydrogenase between the two groups; after the treatment, the content of serum glutamate dehydrogenase in the intervention group was lower than that in the control group (P<0.05). There was no difference in serum MDA between the two groups before treatment, while, After treatment, the serum MDA content of the combined group decreased significantly, which was lower than that of the drug group (P<0.05). There was no difference in serum NSE content between the two groups before treatment; after treatment, the serum NSE content of the intervention group was significantly lower than that of the control group (P<0.05). Conclusion: In the treatment of hyperbilirubinemia, the combination of blue light irradiation and comprehensive treatment has a good effect. It not only effectively reduces the bilirubin content, but also protects children's nerve function, which has an extremely important clinical application value.
李克泉, 刘美, 薛见珍. 综合治疗联合蓝光照射对新生儿溶血伴高胆红素血症患儿血清指标的调节作用[J]. 河北医学, 2020, 26(8): 1273-1276.
LI Kequan, et al. Regulatory Effect of Comprehensive Treatment with Blue Light Irradiation on Serum Indexes of Neonatal Hemolysis with Hyperbilirubinemia. HeBei Med, 2020, 26(8): 1273-1276.
2020, Vol. 26 
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