Abstract：Objective: To investigate the relationship between the levels of C-reactive protein (CRP), serum troponin T (cTnT), thymic stromal lymphopoietin (TSLP), miR-30c-5p and the severity of coronary artery disease in patients with stable angina pectoris (SAP). Methods: The clinical data of 90 SAP patients confirmed by coronary angiography (CAG) admitted to the hospital from May 2016 to May 2019 were retrospectively analyzed. They were divided into mild groups according to SYNTAX score (0~22 points, 41 cases). , Moderate group (23~32 points, 32 cases), Severe group (≥33 points, 17 cases). Collect clinical data of three groups of patients, collect blood to measure the CRP, cTnT, TSLP, miR-30c-5p levels of the three groups of patients. The severity of coronary artery disease in the three groups of patients was evaluated by SYNTAX score, and CRP, cTnT, Relationship between TSLP, miR-30c-5p levels and SYNTAX score. Results: The CRP, cTnT, TSLP, miR-30c-5p levels, and SYNTAX scores of the three groups of patients were statistically significant (P all<0.05). Pairwise comparisons of LSD-t tests showed statistically significant differences (P all<0.05). Pearson correlation analysis showed that CRP, cTnT, TSLP and SYNTAX scores were significantly positively correlated (P<0.01), while miR-30c-5p was significantly negatively correlated with SYNTAX scores (P<0.01). Conclusion: CRP, cTnT, TSLP, miR-30c-5p levels correlate with the severity of coronary artery disease in patients with stable angina pectoris. Early detection of the above biological markers can help determine the severity of coronary artery disease in patients with stable angina pectoris.
[1] Bolayr HA, Kvrak T, Gunes H, et al.The associaton between serum serglycin level and coronary artery disease severity in patients with stable angina pectoris[J].2018, 76(4):783~790. [2] 王帅, 王新明, 李栋.256层多排螺旋CT冠状动脉成像在稳定型和不稳定型心绞痛中的诊断价值[J].医学影像学杂志, 2016, 26(12):2212~2215. [3] 吕晓佟, 刘鑫, 王雪, 等.AMI患者血清S100A12水平与冠状动脉病变严重程度的关系[J].临床心血管病杂志, 2018, 34(6):588~592. [4] Ender Ornek, Alparslan Kurtul.Relationship of mean platelet volume to lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris[J].Coronary Artery Disease, 2017, 28(6):492~497. [5] Emet S, Elitok A, Onur I, et al.Endocan:a novel biomarker associated with well-developed coronary collateral circulation in patients with stable angina and chronic total occlusion[J].Journal of Thrombosis & Thrombolysis, 2016, 43(1):1~8. [6] Francis R.Joshi, Luigi Biasco, Frants Pedersen, et al.Invasive angiography and revascularization in patients with stable angina following prior coronary artery bypass grafting:Results from the East Denmark heart registry:Results From the East Denmark Heart Registry[J]. Catheterization & Cardiovascular Interventions Official Journal of the Society for Cardiac Angiography & Interventions, 2016, 89(3):341~349. [7] 周晓斌.冠心病患者血浆BNP及hs-CRP水平变化与冠状动脉病变程度的关系研究[J].河北医学, 2015, 21(7):1070~1073. [8] 彭明, 肖杰, 王岚, 等.稳定型心绞痛患者血浆甘氨酸与冠状动脉SYNTAX积分的关系[J].中国动脉硬化杂志, 2019, 27(9):769~773. [9] 王静怡, 王志武, 刘素丽, 等.稳定型心绞痛患者血浆炎性因子水平及意义[J].中国医药, 2016, 11(2):162~164. [10] 王晓艳, 应光荣, 骆金伟, 等.N端脑钠肽前体、高敏C反应蛋白、左心室射血分数与不同类型冠心病及冠脉病变程度相关性分析[J].医学研究杂志, 2016, 45(4):126~129. [11] 黄增旭, 宋耀明.不稳定性心绞痛患者超敏肌钙蛋白T与冠状动脉SYNTAX评分相关性分析[J].检验医学与临床, 2016, 13(10):1339~1341. [12] 陈宝峰, 邓芸, 徐新, 等.血清胸腺基质淋巴细胞生成素与稳定型心绞痛患者内皮功能和冠状动脉病变的关系[J].中国心血管病研究, 2019, 17(2):139~142. [13] 杨红, 杨波.心绞痛病人冠状动脉血管超声特征及与血清炎性因子水平的相关性分析[J].中西医结合心脑血管病杂志, 2019, 17(12):1881~1883. [14] 耿汉科, 刘雅静.冠心病患者血浆miR-125b-5p表达变化及其与疾病严重程度关系研究[J].中国医药导刊, 2019, 21(1):12~16. [15] 左红, 侯文兵.血浆微小RNA-30c-5p水平与稳定型心绞痛患者冠状动脉病变严重程度的相关性[J].临床内科杂志, 2019, 36(1):32~35.
2020, Vol. 26 
冀公网安备13080202000677号