Abstract：Objective: To investigate the clinical efficacy of butylphthalide soft capsule in the treatment of early senile Parkinson's disease (PD) and analyze its possible mechanism through the change of serological indexes. Methods: 82 PD patients from January 2017 to December 2018 were selected and divided into control group and observation group according to the random number table, 41 cases each. Two groups of patients were given dopaminergic drugs, the observation group on this basis combined with soft capsules of butylphthalide oral, the treatment cycle was 12 weeks. Before and after treatment, Hoehn & Yahr classification (H-Y classification) and mds-updrs (Part 1 and Part 3) were used to evaluate the clinical efficacy. Meanwhile, the activities of superoxide dismutase (SOD), malondialdehyde (MDA), interleukin-6 (IL-6) and neuron specific enolase (NSE) were measured. Results: The MDS-UPDRS-1, MDS-UPDRS-3, and HY scores of Parkinson's disease patients in the observation group after treatment were lower than those in the control group. After treatment in the control group, their SOD, MDA, Both IL-6 and NSE improved in different degrees. After treatment, their SOD activity in the observation group increased significantly compared with that before treatment, and their MDA, IL-6, and NSE significantly decreased compared with before treatment. The difference was statistically significant (P<0.05). Conclusion: The Butylphthalide soft capsules combined with Dopaminergic drugs can reduce the H-Y grade, MDS-UPDRS-1, MDS-UPDRS-3 scores of early PD patients, improve their SOD, MDA, IL-6, NSE levels, and improve the prognosis of patients with PD.
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2020, Vol. 26 
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