Abstract：Objective: To explore the clinical study on changes of serum Amino-terminal pro-brain natriuretic peptide (NT-proBNP), Bone morphogenetic protein -7 (BMP-7) and Transforming growth factor-β1 (TGF-β1) levels in premature infants with respiratory distress syndrome (RDS). Methods: A total of 106 premature infants with RDS diagnosed in the hospital from April 2016 to April 2018 were selected, and another 53 premature infants with non-RDS of the same age group at the same time period were collected as control group. The expression levels of NT-proBNP, BMP-7 and TGF-β1 in serum samples of premature infants were detected by ELISA in the two groups. The correlation between NT-proBNP, BMP-7 and TGF-β1 and disease severity was analyzed by Pearson correlation analysis. The ROC curve was used to analyze its diagnostic value for RDS. Results: Compared with control group, the expression levels of BMP-7, NT-proBNP and TGF-β1 in serum of RDS patients were significantly increased (P<0.05). Serum NT-proBNP, BMP-7 and TGF-β1 in premature infants with RDS were positively correlated with disease severity (r=0.402, P=0.000; r=0.311, P=0.018; r=0.313, P=0.015). The cut-off value, sensitivity, specificity and AUC of NT-proBNP in the diagnosis of premature infants with RDS were 3655.92 ng/L, 88.7%, 3.8% and 0.985. The cut-off value, sensitivity, specificity and AUC of BMP-7 diagnosis were 44.85 ng/L, 63.2%, 11.3% and 0.829. The cut-off value, sensitivity, specificity and AUC of TGF-β1 diagnosis were 36.73 g/L, 81.1%, 17.0% and 0.829. The sensitivity, specificity and AUC of BMP-7 combined with TGF-β1 were 89.6%, 15.1% and 0.934. Conclusion: The levels of serum NT-proBNP, BMP-7 and TGF-β1 in RDS patients are significantly increased, and their expression levels are positively correlated with disease severity, and they are expected to be diagnostic and prognostic markers.
戚昌丽, 张雅琴, 李敏, 王文慧. 呼吸窘迫综合征早产儿血清NT-proBNP BMP-7及TGF-β1水平变化的临床研究[J]. 河北医学, 2020, 26(7): 1178-1181.
QI Changli, et al. A Clinical Study on Changes of Serum NT-proBNP BMP-7 and TGF-β1 Levels in Premature Infants with Respiratory Distress Syndrome. HeBei Med, 2020, 26(7): 1178-1181.
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2020, Vol. 26 
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