Abstract：Objectives: To investigate the effect of ulinastatin on serum inflammatory factors and intestinal mucosal barrier function in patients with severe acute pancreatitis (SAP). Methods:From January 2015 to January 2019, 80 patients with SAP in Gastroenterology Department of our hospital were selected as the main subjects of study and divided into treatment group (n=41, treated with ulinastatin on the basis of routine treatment) and control group (n=39, treated with routine treatment) according to the random digital table method. Analysis was applied to the changes of serum inflammatory factors [tumor necrosis factor-α (TNF- α) and IL-6, 10, 17 (IL-6,IL-10,IL-17)] in the two groups before and after treatment, and the changes of intestinal barrier function index [endotoxin (ET), serum intestinal fatty acid binding protein (IFABP), diamine oxidase (DAO), D-lactic acid (D-Lac)]. The therapeutic effect and mortality after 7 days of SAP were observed. Results: The total effective rate in the treatment group was 92.68%, which was significantly higher than that in the control group (76.92%, P<0.05). Comparatively, the levels of TNF-1, IL-6, IL-10, IL-17, ET, IFABP, DAO and D-Lac in both groups decreased significantly, while IL-10 increased significantly (Pall< 0.01), after treatment. Compared with the control group, the levels of serum inflammatory factors and intestinal barrier function in the treatment group were significantly improved(Pall< 0.01).The 7-day-mortality rate of the treatment group was 4.88%, which was significantly lower than that of the control group (20.51%,P<0.05). Conclusion: Ulinastatin could significantly inhibit the level of serum inflammatory factors in patients with SAP, improve the protective effect of intestinal mucosal barrier and reduce the short-term mortality of SAP patients. The curative effect is ideal.So it has clinical application value.
陈颖, 刘正爱, 方亮, 陈会, 吴继雄. 乌司他丁对重症急性胰腺炎患者血清炎症指标及肠道黏膜屏障功能改善作用[J]. 河北医学, 2020, 26(6): 983-987.
CHEN Ying, LIU Zheng'ai, FANG Liang, et al. Effect of Ulinastatin on Serum Inflammatory Indexes and Intestinal Barrier Function in SAP Patients. HeBei Med, 2020, 26(6): 983-987.
2020, Vol. 26 
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