Abstract：Objective:To investigate the effect of autotransfusion on interleukin-8 (IL-8) and C-reactive protein (CRP) in patients undergoing cardiopulmonary bypass (CPB). Methods:100 patients who underwent CPB cardiac surgery in our hospital from March 2018 to March 2019 were selected,who were treated with self blood recovery and transfusion. According to the estimated CPB time courses, they were divided into group A (n=32, time course>120min), group B (n=30, time course:60 min~120 min) and group C (n=38, time course<60 min). The IL-8 and CRP were detected in each group, and the blocking time of ascending aorta and the bleeding volume during operation and related indicators were observed. Results:The blocking time and bleeding volume of ascending aorta in group A were (103.30 ± 25.50) min and (810.01 ± 101.11) ml, which were significantly higher than those in group B and group C (P < 0.05); The blocking time of ascending aorta and bleeding volume in group B were (63.30 ± 19.28) min and (430.02 ± 101.11) ml, which were significantly higher than those in group C (P < 0.05); The levels of IL-8 and CRP in group A at 24 and 48 hours after CPB were (18.30 ± 2.20) ng / L and (16.80 ± 1.88) ng/L, (65.59 ± 11.29) ng/L and (48.89 ± 12.10) ng/L, which were significantly higher than those in group B and C (P < 0.05); The levels of IL-8 and CRP in group B 24 and 48 hours after CPB were (15.50 ± 1.88) ng/L and (13.38 ± 2.01) ng/L, (49.89 ± 12.10) ng/L and (30.28 ± 10.11) ng/L, which were significantly higher than those in group C (P < 0.05); The time of tracheal extubation and postoperative hospitalization in group A were (19.20 ± 2.10)h and (12.10 ± 2.10) d, which were significantly longer than those in group B and group C (P < 0.05); The incidence of postoperative neurological complications in group A was 28.13%, which was significantly higher than that in group C (P < 0.05). Conclusion:The longer the CPB time course, the more serious the inflammatory response of patients under the condition of autotransfusion.
夏夏, 黄铭, 朱睿. 自体血回收-回输对不同时程CPB下心脏手术患者IL-8 CRP蛋白的影响[J]. 河北医学, 2020, 26(6): 967-970.
XIA Xia, HUANG Ming, et al. The Effects of Autotransfusion on the Levels of IL-8 and CRP in Patients Undergoing Cardiac Surgery Under CPB in Variant Time Courses. HeBei Med, 2020, 26(6): 967-970.
[1] 刘爱杰,柳国强,夏婧,等.自体血回收-回输对不同时程体外循环下心脏手术患者炎症反应的影响[J].中华麻醉学杂志,2017,37(10):1171~1175. [2] QiuZ,ChenX,XuY,et al.Does full sternotomy have more significant impact than the cardiopulmonary bypass time in patients of mitral valve surgery[J].Journal of Cardiothoracic Surgery,2018,13(1):29~31. [3] 黄毅婷,HUANGYiting.自体血液回输技术在体外循环心脏外科手术中的应用及效果观察[J].中国现代医生,2017,55(20):9~12. [4] Adiraju S K S,ShekarK,Fraser J F,et al.Effect of cardiopulmonary bypass on cytochrome P450 enzyme activity:implications for pharmacotherapy[J].Drug Metabolism Reviews,2017,50(2):1~16. [5] SacutoT,SacutoY.Cardiopulmonary bypass does not induce lung dysfunction after pulmonary thrombarterectomy:role of pulmonary compliance[J].Interactive Cardiovascular & Thoracic Surgery,2017,25(6):930~936. [6] saJungner,ValliusS,BruschettiniM,et al.Cardiopulmonary bypass in the newborn:effects of circulatory cell-free hemoglobin and hyperoxia evaluated in a novel rat pup model[J].Intensive Care Medicine Experimental,2017,5(1):45~46. [7] 王龙,高夏,乔利阳.自体血液回输对成人心脏瓣膜置换术患者血液携氧功能的影响[J].中华解剖与临床杂志,2017,22(4):312~316. [8] 钟恒芳,莫艳祯,卢映君,等.自体血液回收机在心脏瓣膜置换术中的应用研究[J].广西医科大学学报,2017,34(8):1206~1209. [9] Stasko A J,Stammers A H,Mongero L B,et al.The influence of intraoperative autotransfusion on postoperative hematocrit after cardiac surgery:a cross-sectional study[J].The Journal of extra-corporeal technology,2017,49(4):241~248.
2020, Vol. 26 
冀公网安备13080202000677号