Abstract：Objective: To observe the effect of Pramiphene eye drops on the corneal endothelium and lacrimal inflammatory index during cataract surgery perioperative period. Methods: Totally 580 cases (610 eyes) of cataract patients in our hospital, from January 2018 to September 2019, were randomly divided into two groups. Levofloxacin Eye Drops and Tobramycin & Dexamethasone Eye Drops were administrated to the control group (290 cases (302 eyes). On the basis of control group treatment, Pramiphene Eye Drops was administrated to the observation group (290 cases, 308 eyes). The corneal endothelium and lacrimal inflammation indexes were compared between the two groups. Results: There was no significant difference between the observation group and the control group in the loss rate of corneal endothelial cells at 1 week, 1 month and 3 months after operation (P > 0.05); there was no difference between the two groups in the index of lacrimal inflammatory factor IL-6 before operation, and the index of TNF in the observation group was significantly lower than that in the control group (P < 0.05). The difference was statistically significant (P < 0.05). Conclusion: The administration of Pramiphene Eye Drops in the perioperative period of cataract surgery does not increase the loss rate of corneal endothelial cells, which is beneficial to reducing the level of lacrimal inflammatory factors, and is worthy of clinical reference.
张娟娟, 薛涛, 王 升, 董永孝. 普拉洛芬滴眼液对白内障围手术期角膜内皮和泪液炎性指标的影响[J]. 河北医学, 2020, 26(6): 1010-1012.
ZHANG Juanjuan, XUE Tao, WANG Sheng, et al. The Effect of Pramiphene Eye Drops on Corneal Endothelium and Lacrimal Inflammatory Index During Cataract Surgery Perioperative Period. HeBei Med, 2020, 26(6): 1010-1012.
2020, Vol. 26 
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