Effect of Trimebutin Maleate and Stomach Granules Combined with Mosapride on Functional Dyspepsia and Its Effects on Serum 5-HT NO SP and Gastrointestinal Hormone
LI Wen, DING Yuanyuan, LIU Chenchen, et al
The First People's Hospital of Jining City, Shandong Jining 272000, China
Abstract：Objective: To discuss the therapeutic effect of trimebutin maleate and stomach granules combined with mosapride on functional dyspepsia and its effects on serum 5-hydroxytryptamine (5-HT), nitric oxide (NO) and substance P (SP) and gastrointestinal hormone. Methods: 82 patients with functional dyspepsia admitted to our hospital from March 2015 to March 2016 were selected and divided into control group and research group according to simple random method, 41 in each. The control group was given medication treatment of mosapride, and the research group was additionally given trimebutin maleate on the basis of control group.Then the clinical curative effect, changes of symptom score, the serum levels of 5-HT, NO and SP, motilin (MTL), gastrin (GAS), gastric antrum movement index (MI), amplitude (ΔA/A), the contraction frequency (F), gastric half emptying time (T1/2) before and after the treatment, and incidence of adverse reactions were compared between both groups. Results: The total effective rate of research group was higher than that of the control group (P<0.05); After treatment, the levels of serum 5-HT, NO, T1/2 in both groups decreased, and the levels of serum SP, MTL, GAS, MI, ΔA/A, F in both groups increased. Moreover, the differences between the above indexes in the research group before and after treatment were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). Conclusion: The therapeutic effect of trimebutin maleate combined with mosaprib in the treatment of functional dyspepsia is superior to that of mosaprib alone, which may be related to the effective regulation of serum 5-ht, NO and SP levels in patients and the improvement of gastrointestinal hormones
李稳, 丁媛媛, 刘晨晨, 刘立芬. 马来酸曲美布汀联合莫沙比利对功能性消化不良的治疗效果及对血清5-HT NO SP与胃肠激素的作用研究[J]. 河北医学, 2020, 26(5): 740-744.
LI Wen, DING Yuanyuan, LIU Chenchen, et al. Effect of Trimebutin Maleate and Stomach Granules Combined with Mosapride on Functional Dyspepsia and Its Effects on Serum 5-HT NO SP and Gastrointestinal Hormone. HeBei Med, 2020, 26(5): 740-744.
2020, Vol. 26 
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