Abstract：Objective: To explore the role of concentrated growth factor (CGF) complex silk fibroin-hydroxyapatite scaffold in promoting the repair of rabbit mandibular defects. Methods: 48 healthy New Zealand white rabbits were randomly divided into 3 groups, 16 in each group. The right mandibular bone defect model was prepared at the same time. Group A was a composite material group, and group B was a hydroxyapatite group implanted with hydroxyapatite materialGroup C No material is implanted for the blank group. All animals were harvested at 2, 4, 8, and 12 weeks, and tissue samples were prepared. The results were observed in general observation, imaging, and histological analysis. The imaging analysis values were collected and evaluated. The analysis results were analyzed by SPSS17.0. P<0.05 was statistically significant. Results: Gross observation and imaging analysis showed that the new bone condition and osteogenesis rate of group A were significantly better than those of the other two groups. The bone mineral density analysis and new bone area measurement also showed the superiority of composite materials in promoting osteogenesis. Conclusion: Concentrated growth factor (CGF) combined with silk fibroin hydroxyapatite scaffolds showed a good osteogenic effect in the experiment of promoting jaw defects, with obvious osteoinductive effect, which is expected to become a new material for clinical bone defect repair.
2020, Vol. 26 
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