Abstract：Objective: To study the effect of intermittent epidural administration on labor analgesia and the effects of neuron specific enolase (NSE), S100β protein (S100β) and amyloid β protein (Aβ) in primipara. Methods: 86 primiparas received labor analgesia from January 2018 to March 2019 in our hospital were selected into the study object. They were divided into observation group and control group by simple random grouping method, 43 cases in each group. Two groups of patients were given epidural labor analgesia, the observation group of epidural regular intermittent administration, the control group of epidural continuous administration. The changes of vas, NSE, S100 β and a β levels before and after analgesia were compared between the two groups. In addition, the delivery mode and adverse reactions during analgesia were compared between the two groups. Results: There was no significant difference in VAS score between the two groups at different time points before and after analgesia (P>0.05).The VAS score of the two groups at different time points after analgesia was significantly lower than that before analgesia (P<0.05).The natural delivery rate in the observation group was significantly higher than that in the control group, and the rates of vaginal midwifery and cesarean section were significantly lower than those in the control group (P<0.05).There was no significant difference in NSE, S100β and Aβ levels between the two groups before and after analgesia (P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups (9.30% vs 16.28%) during analgesia (P>0.05). Conclusion: Both regular intermittent epidural administration and continuous epidural administration can be used for labor analgesia of primipara with satisfactory analgesic effect and low incidence of adverse drug reactions. They can maintain the balance of NSE, S100β and Aβ. In contrast, regular intermittent epidural administration has the advantage of high natural delivery rate and has high clinical application value.
刘玉梅, 王占晖, 张秀欣, 宋秀云. 硬膜外规律间断给药对初产妇分娩镇痛效果分析及对NSE S100β和Aβ的影响分析研究[J]. 河北医学, 2020, 26(4): 677-681.
LIU Yumei, WANG Zhanhui, ZHANG Xiuxin, et al. Analysis of the Analgesic Effect of Intermittent Epidural Administration on Primipara and its Influence on NSE S100 β and a β. HeBei Med, 2020, 26(4): 677-681.
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2020, Vol. 26 
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