Clinical Analysis of the Relationship between Serum S-100 β and Sleep Disorder and Cognitive Function in the Elderly Patients with Acute Cerebral Infarction
FENG Hao, LIU Wei, TANG Xiaomei
Haidian District, the Third Hospital of Peking University, Beijing Haidian District 100080, China
Abstract:Objective: To study the relationship between serum S-100 β and sleep disorder and cognitive function sleep in elderly patients with acute cerebral infarction. Methods: 216 elderly patients with acute cerebral infarction admitted to our hospital from May 2015 to May 2019 were divided into group A (with non-rapid eye movement sleep disorder, 112 cases) and group B (without non-rapid eye movement sleep disorder, 104 cases).All patients accept guide more sleep monitoring, compared two groups of total sleep time (TST), sleep latency (SOL), number of awakening (WUT), sleep efficiency (SE) and rapid eye movement (REM) sleep period (REMT), REM sleep time period of total sleep time percentage(REM%) sleep and non-rem sleep (NREM) sleep stage S1, S2, S3 + S4 sleep time.Montreal Cognitive Assessment Scale (MOCA) was used to assess the cognitive function of the two groups. Serum S-100beta level and its relationship with sleep parameters and cognitive function were analyzed. Results: The sleep time of TST, SE, REMT, REM% and NREM in group A was significantly lower than that in group B (P<0.05), while the sleep time of SOL, WUT and NREM in stage S1 was significantly higher than that in group B (P<0.05).The scores of visual space and executive function, attention, delayed memory, orientation and MOCA in group A were significantly lower than those in group B (P<0.05), but there was no significant difference in naming, language and abstract scores between group A and group B (P>0.05).Serum S-100beta level in group A was significantly lower than that in group B (P<0.05). In elderly patients with acute cerebral infarction with non-rapid eye movement sleep disorder, serum s-100 was negatively correlated with TST, SE, REMT, REM%, S2, S3+S4 (r=-0.466, -0.682, -0.612, -0.646, all P<0.05), positively correlated with SOL, WUT, and S1 (r=0.435, 0.587, 0.187, all P<0.05), and negatively correlated with the total score of MOCA (r=-0.327, P<0.05). Conclusion: Serum S-100beta is associated with sleep quality and cognitive function in elderly patients with acute cerebral infarction and non-REM sleep disorder.
冯浩, 刘伟, 唐晓梅, 于逢春. 血清S-100β与老年急性脑梗死患者非快速眼动期睡眠障碍及认知功能关系的临床分析[J]. 河北医学, 2020, 26(4): 625-630.
FENG Hao, LIU Wei, TANG Xiaomei. Clinical Analysis of the Relationship between Serum S-100 β and Sleep Disorder and Cognitive Function in the Elderly Patients with Acute Cerebral Infarction. HeBei Med, 2020, 26(4): 625-630.
[1] 陈思梅.联合检测Hcyhs-CRP在冠心病合并急性脑梗死患者中的预测作用研究[J].河北医学,2016,22(5):870~873. [2] 戴海琳,王丽,王彦珍,等.进展性脑梗死患者睡眠结构变化的研究[J].中国现代医学杂志,2018,28(7):109~111. [3] 吴瑜,梁慧,欧阳锋.脑梗死后伴发睡眠障碍的相关因素分析[J].脑与神经疾病杂志,2019,27(8):463~467. [4] Yildirim AO, Eroglu M, Kaldirim U, et al. Serum neuron-specific enolase and S-100β levels as prognostic follow-up markers for oxygen administered carbon monoxide intoxication cases[J]. Indian Biochem Biophys, 2015, 52(1):29~33. [5] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146~153. [6] Nasreddine ZS , Phillips NA , Bedirian V, et al. The montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment[J].Am Geriatr Soc, 2005, 53(4):695~699. [7] Porter VR, Avidan AY. Clinical overview of REM sleep behavior disorder[J]. Semin Neurol, 2017, 37(4):461~470. [8] Bruni O, Ferri R, Novelli L, et al. Slow EEG amplitude oscillations during NREM sleep and reading disabilities in children with dyslexia[J]. Dev Neuropsychol, 2016, 34(5):539~551. [9] Scarpelli S, D'Atri A, Mangiaruga A, et al. Predicting dream recall: EEG activation during NREM sleep or shared mechanisms with wakefulness[J]. Brain Topogr, 2017, 30(5):629~638. [10] 李成博,李敏,于宁,等.睡眠障碍与脑卒中发病关系研究进展[J].中国老年学,2017,37(8):2057~2059. [11] 丁岩,常红,詹淑琴,等.首次急性缺血性卒中患者发病前睡眠障碍的调查[J].北京医学,2017,39(5):468~471. [12] Plante DT, Goldstein MR, Cook JD, et al. Effects of partial sleep deprivation on slow waves during non-rapid eye movement sleep: A high density EEG investigation[J]. Clin Neurophysiol, 2016, 127(2):1436~1444. [13] Tarokh L, Rusterholz T, Achermann P, et al. The spectrum of the non-rapid eye movement sleep electroencephalogram following total sleep deprivation is trait-like[J].Sleep Res, 2015, 24(4):360~363.