Abstract：Objective:To explore the reference value of Down's syndrome screening with AFP, HCG, UE3 and inhibin A in the second trimester of pregnancy, so as to provide theoretical and practical basis for predicting the risk rate of pregnant women and children with Down's syndrome and for further screening and diagnosis and treatment according to the risk rate.Methods: A retrospective analysis was made of 201 singleton pregnant women (7 fetuses with Down's syndrome) who were successfully screened and followed up in our hospital from March 2017 to March 2018. To detect HCG,AFPand UE3 、inhibin A . thethree-and four-way screening of Down's syndrome risk values were calculated by suss related parameters, and the effect of different cut value levels on Down's syndrome screening was analyzed.Result: In 201 subjects, the total abnormal rate of mom in different age groups was 24.88%, in which the abnormal rates of HCG, AFP, uE3 and inhibin A were 8.96%, 9.95%, 1.99% and 3.98% respectively. There were 7 cases (3.48%) of chromosomal abnormalities in amniocentesis. Among them, 5 cases (71.43%) had abnormal mom value ≥1. The incidence of chromosomal abnormalities in normal mom was 1.32% (2/151) which was 10.00% (5/50) higher than that in abnormal mom (P<0.05).the SURSS calculation showed that the false-positive rate of AFP+uE3+HCG+Inhibin A was 3.12%, 5.75% and 7.68% respectively, which was 0.85%, 2.01% and 3.52% lower than that of triple screening. The false positive rate of quadruple screening was significantly lower than that of double screening and single screening (P<0.05). Pearson's score showed that Inhibin A was positively correlated with HCG and AFP in normal pregnant women, but negatively correlated with HCG and AFP in Down's syndrome pregnant women (P<0.05),There was no correlation between inhibin A and uE3 (P > 0.05).Conclusion:In the mid pregnancy screening of Down's syndrome, scientific and reasonable HCG+AFP+uE3+inhibin A quadruple screening is more effective and has good clinical application and promotion value.
朱艳菊, 阚长利, 肖艳平, 付久园. 孕中期四联筛查唐氏综合征的参考价值[J]. 河北医学, 2020, 26(4): 615-619.
ZHU Yanju, KAN Changli, XIAO Yanping, et al. The Reference Value of Quadruple Screening Down's Syndrome in the Second Trimester. HeBei Med, 2020, 26(4): 615-619.
2020, Vol. 26 
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