Effect of Mechanical Thrombectomy Combined with Catheter Thrombolysis on Coagulation Function, Recurrence and Amputation in Patients with Acute Lower Extremity Arterial Embolism
WU Ligang, ZENG Hanqiang
Dongguan People's Hospital, Guangdong Dongguan 523000, China
Abstract：Objective: To analyze the effects of mechanical thrombectomy combined with catheter thrombolysis on coagulation function, recurrence and amputation in patients with acute lower extremity arterial embolism. Methods: 84 patients with acute lower extremity arterial embolism in our hospital from January 2016 to August 2018 were randomly divided into study group and control group, 42 cases in each group. The control group was treated with mechanical thrombectomy, and the study group was treated with catheter thrombolysis on this basis. After treatment, the clinical treatment and coagulation function [including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (FIB), D-Dimer (D-D)] of the two groups were compared, and the amputation rate and recurrence rate of the two groups were compared. Results: After treatment, the total effective rate of the study group was significantly higher than that of the control group (P<0.05). The levels of FIB and D-D in the two groups were significantly lower than those before treatment, and PT and APT were significantly higher than those before treatment (P<0.05); the levels of FIB and D-D in the study group were significantly lower than those in the control group, and PT and APT were significantly higher than those in the control group (P<0.05). The recurrence rate of the study group was significantly lower than that of the control group (P<0.05), but there was no significant difference in amputation rate between the two groups (P>0.05). Conclusion: Mechanical thrombectomy combined with catheter thrombolysis can significantly improve the coagulation function of patients with acute lower extremity arterial embolism, better reduce the recurrence rate, lower the risk of amputation, clinical efficacy is clear.
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2020, Vol. 26 
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