Abstract：Objective: To investigate the correlation between serum uric acid with coronary artery calcification in patients with chronic kidney disease (CKD). Methods: 142 patients with CKD hospitalized in Chongqing Three Gorges Central Hospital from April 2016 to January 2019 were selected as the research subjects. The arterial calcification was monitored by X-ray at admission. And Simultaneous determination of serum uric acid (UA), urea nitrogen (BUN), serum creatinine (SCr), serum calcium and other blood biochemical indicators. According to the results of coronary artery calcification, the patients were divided into calcification group (66 cases) and non-calcification group (76 cases), Arterial calcification scores and UA levels after hemodialysis were measured, the relationship between Arterial calcification scores with UA and the risk factors of coronary artery calcification were analyzed. Results: The TG, CRP, 24h urinary protein, proportion of hypertension and chronic nephritis history in calcification group were significantly higher than those in non-calcification group (P<0.05), while Hb and eGFR were lower than those in non-calcification group (P<0.05); the UA level before dialysis in calcification group was higher than that in non-calcification group (P<0.05), and the calcification scores and UA level after dialysis were lower than those before dialysis (P<0.05); there was a positive correlation between Arterial calcification scores with UA level in CKD patients (P<0.05); UA and eGFR were risk factors for coronary artery calcification in CKD patients. Conclusion: Serum uric acid can aggravate arterial calcification in patients with CKD. Early intervention of uric acid therapy and adequate dialysis may be an effective way to improve arterial calcification.
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2020, Vol. 26 
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