Abstract：Objective: To investigate the effects of simvastatin on vascular endothelial function and hemorheology in patients with coronary heart disease and angina pectoris. Methods: 84 patients with coronary heart disease and angina pectoris admitted to our hospital from January 2015 to February 2017 were selected. The patients were divided into experimental group and control group by random number table method, 42 cases in each group. Patients in the control group were treated with routine regimen, while patients in the experimental group were treated with simvastatin on the basis of routine regimen. The vascular endothelial function and hemorheological parameters were compared between the two groups. Results: After treatment, the frequency and duration of angina pectoris attacks in the experimental group were less than those in the control group (3.14 (+0.32) times/week and (3.05 (+0.46) times/min), CK-MB (32.15 (+5.32) ug/L), LDH (147.21 (+13.22) ug/L), CRP (4.02 (+0.59) mg/L and FIB (3.11 (+0.52) g/L levels were lower than those in the control group, and there were significant differences between the two groups. (P<0.05). The levels of ET (55.42 + 2.92) ng/L and TXB2 (93.23 + 6.26) ng/L in the experimental group were significantly lower than those in the control group after treatment, with a significant difference between the two groups (P<0.05). The whole blood viscosity, plasma viscosity, hematocrit and fibrinogen levels in the experimental group were significantly lower than those in the control group (P<0.05). Conclusion: Simvastatin can effectively improve vascular endothelial function and hemorheological parameters in patients with coronary heart disease and angina pectoris. It is effective and worth recommending.
吕丹, 金大鹏, 王文丰, 王鹏飞. 辛伐他汀对冠心病心绞痛患者血管内皮功能及血液流变学的影响[J]. 河北医学, 2020, 26(4): 568-571.
LV Dan, JIN Dapeng, WANG Wenfeng, et al. Effects of Simvastatin on Vascular Endothelial Function and Hemorheology in Patients with Coronary Heart Disease and Angina Pectoris. HeBei Med, 2020, 26(4): 568-571.
2020, Vol. 26 
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