Abstract：Objective: To observe the expressions of microRNA-210 (miR-210) and hypoxia inducible factor-1α (HIF-1α) in endometrial polyps (EP) and their clinical significances. Methods: From June 2018 to May 2019, 62 patients with endometrial polyps diagnosed by hysteroscopy and resected in our hospital were selected as the study subjects, called polyps group, and 62 normal endometrial patients with infertility or uterine malformations who underwent hysteroscopy and excluded EP during the same period were selected as the control study, called normal endometrium group. The levels of prolactin (PRL), estradiol (E2), testosterone (T), follicle stimulating hormone (FSH) and progesterone (P) were measured by enzyme-linked immunosorbent assay (ELISA), the relative expression levels of miR-210, HIF-1α, estrogen receptor (ER), progesterone receptor (PR) and vascular endothelial growth factor (VEGF) were detected by real-time fluorescence quantitative analysis (qRT-PCR), Pearson method was used to analyze the correlation between the expression levels of miR-210, HIF-1α and ER, PR, VEGF, and the expression levels of miR-210 and HIF-1α in EP tissues. Results: There was no significant difference in serum PRL, E2, T, FSH and P levels between EP patients and normal endometrium (P>0.05). The expression levels of miR-210, HIF-1α, ER and VEGF in polyps were significantly higher than those in normal intima group (P<0.05), and the expression levels of PR were significantly lower than those in normal intima group (P<0.05). MiR-210 was positively correlated with the expression of VEGF (P<0.05), HIF-1α was positively correlated with the expressions of ER and VEGF (P<0.05), and negatively correlated with the expression of PR (P<0.05). The expression level of miR-210 was positively correlated with HIF-1α (P<0.05). Conclusions: The expression of mir-210 and HIF-1 α in endometrial polyps of EP patients was up-regulated, and there was a positive correlation between them.
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2020, Vol. 26 
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