Abstract：Objective: To study the relationship between control blood lipid level, erythrocyte distribution width (RDW) and endothelin-1 (ET-1) and in-stent restenosis (ISR) after percutaneous coronary intervention (PCI) in patients with coronary heart disease (CHD). Methods: A total of 108 patients with coronary heart disease underwent PCI in our hospital from January 2016 to January 2019 were enrolled. Coronary angiography was performed 3 to 12 months after surgery. Patients were divided into ISR group according to angiographic results. There were 17 cases and 91 cases of non-ISR group. Blood lipid levels [total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)] were measured before PCI and before coronary angiography. The levels of RDW and ET-1 were measured before coronary angiography, and the relationship between serum lipid levels, RDW and ET-1 and ISR in patients with CHD after PCI was analyzed. Results: The levels of TC, TG, and LDL-C before coronary angiography in the ISR group were significantly higher than those in the non-ISR group (P<0.05). The levels of RDW and ET-1 in the ISR group were significantly higher than those in the non-ISR group. The differences were statistically significant (P<0.05). Logistic multivariate regression analysis results showed that TC did not decrease and LDL-C did not meet the target (controlled at 1.8 mmoL/L before coronary angiography) were risk factors for postoperative ISR in patients with coronary heart disease (P<0.05). TG did not decrease and HDL -C is not a risk factor for postoperative ISR in patients with coronary heart disease (P﹥0.05); RDW and ET-1 are risk factors for postoperative ISR in patients with coronary heart disease (P<0.05). Conclusion: TC, LDL-C, RDW and ET-1 are the high risk factors of ISR in patients with CHD after PCI. The detection of TC, LDL-C, RDW and ET-1 is helpful to evaluate the risk of ISR.
刘恒友, 鲁锦国, 刘小河, 王春明, 胡晓军. 血脂控制水平 RDW及ET-1与冠心病患者PCI术后支架内再狭窄的关系研究[J]. 河北医学, 2020, 26(4): 545-549.
LIU Hengyou, LU Jinguo, LIU Xiaohe, et al. Relationship between Serum Lipid Levels RDW and ET-1 andIn-stent Restenosis after PCI in Patients with CHD. HeBei Med, 2020, 26(4): 545-549.
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2020, Vol. 26 
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