Abstract：Objective: To study the relationship between the incidence of ESBLs production by gram-negative bacilli and the bacterial resistance with clinical experience. Methods: For the gram-negative bacilli isolated in our hospital, the improved three-dimensional test was used to detect the esbls-producing strain, and the isolation rate of the ESBLs producing strain was tested. The drug sensitivity test of gram-positive bacilli was used to find out the possible drug production of the ESBLs strain, and the relationship between it and bacterial resistance was analyzed. Results: The clinical detection rate of 732 strains showed that 224 strains of Communist ESBLs, and the detection rate of ESBLs production was 30.60%. There was significant difference in ESBLs detection rate among strains (χ2= 8.162, P < 0.05). According to the number of ESBLs producing strains, Escherichia coli, Klebsiella pneumoniae, Proteus and Klebsiella acidogenes can be arranged from more to less. After comparison, the detection rate of ESBLs producing strains in each department was statistically significant (χ2=19.863, P < 0.05). ESBLs producing strains were mainly distributed in ICU (47.62%), urology (40.00%), respiratory medicine (30.00%) and Neurology (28.57%). The difference of resistance rate of ESBLs producing strains to antibiotics was statistically significant (χ2= 29.016, P < 0.05). The difference of resistance rate of ESBLs producing strains to antibiotics was statistically significant (χ2= 29.016, P < 0.05). The resistance rate of ESBLs producing strains is higher than that of penicillins, but it is highly sensitive to carbapenems. Among them, ampicillin (98.21%), amikacin (96.43%), cefazolin (91.07%),sulbactam (67.86%) and ciprofloxacin (60.71%) are the top three. Conclusion: The detection rate of ESBLs producing bacteria was high in our hospital, mainly Escherichia coli, Klebsiella acidogenes and Klebsiella pneumoniae. The detection rate of ESBLs of gram-negative bacilli is high and it has multiple drug resistance.
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2020, Vol. 26 
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