Abstract：Objective: To investigate the prognosis and effect of conventional therapy combined with alprostadil injection in the treatment of acute ischemic cerebral infarction. Methods: According to a simple random group, 100 patients with acute ischemic cerebral infarction admitted to our hospital from April 2017 to June 2018 were divided into 50 patients in the study group and the control group. The control group received conventional therapy or oral aspirin. Lyric tablets and atorvastatin calcium tablets, intravenous infusion of Shuxuetong injection, the study group was treated with alprostadil injection on the basis of the control group, comparing the two groups of patients before and after treatment Differences in neurological deficit scores (NIHSS), clinical outcomes, and related indicators. Results: After 1 week and 2 weeks of treatment, the ADL and NIHSS scores of the two groups were significantly improved compared with those before treatment (P<0.05). After 1 week and 2 weeks, the score of the study group improved better than the control group. <0.05). After 1 week and 2 weeks of treatment, CRP, IL-6 and fibrinogen were significantly improved in both groups (P<0.05). After 1 week and 2 weeks, the study group improved. Control group (P<0.05). After 2 weeks of treatment, the total effective rate of the study group was 94%, and that of the control group was 80%. The study group was significantly higher than the control group (P<0.05). The adverse reactions after treatment were counted. In the study group, 1 patient developed mild diarrhea, 3 rashes occurred, 1 patient developed nasal mucosal hemorrhage, and 2 patients had epistaxis in the control group. There were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combination of alprostadil and conventional therapy in patients with acute ischemic cerebral infarction has a significant effect on improving clinical outcomes.
冯源, 韩博. 前列地尔注射液治疗急性缺血性脑梗死疗效及不良反应的研究[J]. 河北医学, 2020, 26(3): 482-485.
FENG Yuan, HAN Bo. Study on the Efficacy and Side Effects of Alprostadil Injection in the Treatment of Acute Ischemic Cerebral Infarction. HeBei Med, 2020, 26(3): 482-485.
2020, Vol. 26 
冀公网安备13080202000677号