Abstract：Objective: To analyze the risk factors of acute kidney injury in patients with septic shock, and to provide reference for early detection of high-risk population and timely prevention of acute kidney injury. Methods: Computer-reviewed literature on risk factors for acute kidney injury in patients with septic shock in CNKI, Wanfang Data Knowledge Service Platform, VIP, CBM, PubMed, Web of Science, The Cochrane Library,using RevMan5.3 to analyze. Results: Nine articles were included, including two cohort studies and seven case-control studies, age [WMD=1.33, 95% CI (-1.73, 4.38), P=0.39], smoking [OR=1.43, 95% CI (1.08, 1.87), P=0.01], drinking [OR=0.90, 95% CI (0.77,1.05), P=0.19], hypertension [OR=1.39, 95% CI (1.19,1.62), P<0.0001], diabetes [OR=1.53, 95% CI (1.38,1.69), P<0.00001], mechanical ventilation [OR= 1.30, 95% CI (1.13, 1.48), P=0.0002], the use of pressure-boosting drugs [OR=2.51, 95% CI (1.35, 4.64).P=0.003],blood transfusion history[OR=3.55,95% CI (1.82,6.91),P=0.0002],contrast medium [OR=3.44, 95% CI (2.03, 5.84), P<0.00001], blood culture positive [OR=1.59, 95% CI (1.17,2.15),P=0.003], APACHEⅡ [WMD=1.96,95% CI (1.49,2.43), P<0.00001], CVP [WMD=3.55, 95% CI (2.89,4.21), P<0.00001]. Conclusion: According to the existing evidence, the risk factors of acute renal injury in septic shock patients are smoking, hypertension, diabetes, mechanical ventilation, use of booster drugs ≥ 2 kinds, blood transfusion history, contrast media, positive blood culture, high Apache Ⅱ score, high CVP.
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2020, Vol. 26 
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