Abstract：Objective: To observe the effects of salbutamol and ketotifen on serum levels of endothelin-1 (ET-1), nitric oxide (NO) and circulating endothelial cells (CEC) in children with asthma. Methods: 80 children with asthma enrolled in our hospital were chosen. According to the odevity of admission order, they were divided into 2 groups, 40 cases in each group. The control group was given routine treatment and salbutamol, the observation group was given ketotifen on the basis of the control group. The lung function indexes [force expiratory volume in the first second (FEV1), vital capacity (FVC), FEV1/FVC, peak expiratory flow (PEF) ], serum levels of ET-1, NO, CEC in the two groups before and after treatment were compared, the symptom regression time, efficacy and adverse reactions of the two groups were observed. Results: The total response rate of the observation group was significantly higher than that of the control group (P<0.05). The FEV1, FVC, FEV1/FVC and PEF of both groups increased significantly after treatment (P<0.05), and the increase in the observation group was significantly greater than that in the control group (P<0.05). However, the serum levels of ET-1, NO and CEC decreased significantly after treatment (P<0.05), and the decrease in the observation group was significantly greater than that in the control group (P<0.05). The fading away time of cough, lung rale, shortness of breath and wheezing symptoms in the observation group was significantly shorter than that in the control group (P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups (P <0.05). Conclusion: Salbutamol combined with ketotifen in the treatment of children with asthma can promote recovery of lung function and clinical symptoms, which nay be related to reduction of serum ET-1, NO and CEC levels, and the safety is high.
陈阿阮, 程元辉, 陈静. 沙丁胺醇与酮替芬联合治疗对小儿哮喘血清ET-1 NO CEC水平的影响[J]. 河北医学, 2020, 26(3): 437-440.
CHEN Aruan, et al. Effect of Salbutamol Combined with Ketotifen on Levels of Serum ET-1 NO and CEC in Children with Asthma. HeBei Med, 2020, 26(3): 437-440.
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2020, Vol. 26 
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