Abstract：Objective: To study the application effect and safety of bi-level positive airway pressure (BiPAP) non-invasive ventilator in the treatment of chronic obstructive pulmonary diseases (COPD) patients in the phase of exacerbation. Methods: A retrospective analysis method was adopted. The study objects were 120 patients with COPD in the phase of acute exacerbation who admitted from June 2016 to June 2019. They were divided into control group and study group according to different treatment methods, 60 cases in each; the control group received conventional treatment, and the study group was administrated BiPAP non-invasive ventilator therapy based on conventional treatment. The blood gas analysis indicators (arterial oxygen pressure, carbon dioxide partial pressure), and D-dimer were compared between the two groups before and after treatment , E-selectin levels and the total effective rate after treatment, the incidence of adverse reactions (dizziness, nausea, vomiting, diarrhea). Results: After treatment, the arterial blood oxygen partial pressure, carbon dioxide partial pressure, D-dimer, hs-CRP, total effective rate and incidence of adverse reactions were (95.14±12.31) mmHg, (47.97±6.03) mmHg, (30.09±4.97) μg/L, (13.68±8.15) mg/L, 96.67%, 5.00%, the indexes of the control group after treatment are (86.43±10.08) mmHg, (60.15±6.81) mmHg, (41.85±5.22) μg/L, (19.25±10.25) mg/L, 85.00%, 6.67%. Compared with the control group, the study group had higher arterial blood oxygen partial pressure and total effective rate, and lower carbon dioxide partial pressure, D-dimer, and hs-CRP levels (P<0.05); the incidence of adverse reactions after treatment in both groups was not different (P>0.05). Conclusion: BiPAP non-invasive ventilator has a significant effect in the treatment of patients with acute exacerbation of COPD. It can effectively improve the blood gas index of patients, reduce the inflammatory response, and has fewer adverse reactions and high safety.
高雅, 李想, 周晓静. BiPAP无创呼吸机治疗COPD急性加重期患者的疗效及安全性[J]. 河北医学, 2020, 26(12): 2021-2023.
GAO Ya, LI Xiang, ZHOU Xiaojing. Efficacy and Safety Analysis of BiPAP Non-Invasive Ventilator in Patients with Acute Exacerbation of COPD. HeBei Med, 2020, 26(12): 2021-2023.
2020, Vol. 26 
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