Abstract：Objective: To explore the correlation between the expression levels of apolipoprotein B (ApoB) and interleukin-18 (IL-18) in the serum of elderly pregnant women and postpartum depression (PPD). Methods: From January 2016 to June 2019, 85 women who met the diagnostic criteria for depression were selected and followed up as required for 42 days after delivery, which was called PPD group; and 87 cases of pregnant women who did not meet the diagnostic criteria for depression during the same period of follow-up were selected for a controlled study, which was made the normal group. The general data of the two groups were compared and analyzed. The level of serum ApoB of all pregnant women was measured by immunoturbidimetry. The level of IL-18 was detected by enzyme-linked immunosorbent assay (ELISA). The Edinburgh Postpartum Depression Scale (EPDS) was used to evaluate the depression status of all pregnant women. Pearson's method was used to analyze the relationships between the levels of serum ApoB, IL-18, EPDS score and total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), and the correlations between the levels of serum ApoB, IL-18 and EPDS score. And the influencing factors of PPD were analyzed by Logistic regression. Results: The levels of serum TC and HDL-C in PPD group were significantly lower than those in normal group (P<0.05), and the levels of ApoB and IL-18, and EPDS score in PPD group were significantly higher than those in normal group (P<0.05). The levels of serum ApoB and IL-18, EPDS score in PPD patients were negatively correlated with TC and HDL-C (P<0.05), and the levels of serum ApoB and IL-18 were positively correlated with EPDS score (P<0.05). TC,HDL-C levels were protective factors of PPD (P<0.05), and high levels of ApoB and IL-18 were risk factors of PPD (P<0.05). Conclusion: The expression levels of ApoB and IL-18 in serum of women with postpartum depression are up-regulated, which may be related to the degree of depressive symptoms. They may play an important role in the occurrence and development of PPD.
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2020, Vol. 26 
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